▲Domain Discovery

Muscle Performance & Recovery

Targets governing muscle protein synthesis, hypertrophy, and recovery. Compounds are ranked by target influence (IDF-weighted), research rarity, and momentum — revealing under-studied candidates with active signal.

Targets:MTORPRKAA1PRKAA2IGF1RMSTNARESR1PPARGPPARA

442 compounds matched · 9 targets active

Top Emerging Muscle Performance & Recovery Compounds

#	Compound	Top Targets	Score	Studies
1	Berberinecap⚡	PRKAA1 · PRKAA2 · PPARA	16.140	300
2	Rutincap⚡	PRKAA2 · PPARG · ESR1	11.242	300
3	chrysincap⚡	PPARG · ESR1 · AR	7.959	300
4	egcgcap⚡	MTOR · AR	6.821	300
5	Quercetincap	IGF1R · PRKAA2 · PPARG	6.689	300
6	Arachidonic Acid⚡	PPARA · PPARG	5.929	245
7	Kaempferolscap	PRKAA2 · PPARG · ESR1	4.465	300
8	ly294002	IGF1R · MTOR	4.123	11
9	trequinsin hydrochloride	PPARG · AR	4.090	1
10	Rotenonecap	PRKAA1 · PRKAA2 · MTOR	3.946	300

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Under-cap onlyAccelerating ⚡50 compounds

#	Compound	Targets	Score	Studies	Evid.
1	Berberinecap⚡ 7% human	PRKAA1PRKAA2PPARA	16.140	300	47.9
2	Rutincap⚡ 2% human	PRKAA2PPARGESR1	11.242	300	41.5
3	chrysincap⚡ 0% human	PPARGESR1AR	7.959	300	39.8
4	egcgcap⚡ 1% human	MTORAR	6.821	300	43.2
5	Quercetincap 1% human	IGF1RPRKAA2PPARGESR1+1	6.689	300	43.4
6	Arachidonic Acid⚡ 8% human	PPARAPPARG	5.929	245	47.4
7	Kaempferolscap	PRKAA2PPARGESR1AR	4.465	300	43.3
8	ly294002	IGF1RMTOR	4.123	11	29.6
9	trequinsin hydrochloride	PPARGAR	4.090	1	7.6
10	Rotenonecap	PRKAA1PRKAA2MTORPPARG+2	3.946	300	36
11	Fluoxetinecap⚡ 42% human	ESR1AR	3.696	1,000	73.4
12	Ursolic Acidcap	PRKAA1PRKAA2PPARAMTOR	3.468	300	42.3
13	Niclosamide 2% human	PRKAA1PRKAA2MTORESR1+1	3.366	299	44.1
14	Metformincap 49% human	PRKAA1PRKAA2	3.044	1,000	71.9
15	Methylene Blue 3% human	MSTNPPARGESR1AR	2.884	200	42.9
16	tyrphostin 9	MTOR	2.865	2	11.5
17	Phenelzine	ESR1AR	2.744	2	7.2
18	Thioctic Acid⚡ 1% human	ESR1	2.537	182	44.6
19	Budesonidecap⚡ 35% human	ESR1AR	2.464	1,000	75.3
20	mg624	ESR1AR	2.441	3	17.7
21	triolimus [Supplementary Concept] 21% human	MTORESR1AR	2.433	33	43.4
22	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	PRKAA1PRKAA2	2.409	76	40.3
23	propyl gallate⚡ 0% human	ESR1	2.375	261	42.3
24	Dehydroepiandrosterone Sulfatecap⚡ 3% human	PPARG	2.326	300	46.8
25	Vitamin K 2cap⚡ 5% human	ESR1	2.318	300	45.1

score = target_influence × rarity × momentum⚡ acceleration >2×cap = ≥300 studies (corpus ceiling)click target chip to filter

About Muscle Performance & Recovery Compound Discovery

Discover emerging muscle performance compounds via mTOR, AMPK, IGF-1R, androgen receptor, and PGC-1α target networks. The discovery score combines three signals: target influence (how strongly a substance interacts with muscle performance & recovery targets, weighted by target specificity via IDF), rarity factor (inverse log of study count — fewer studies means higher discovery potential), and momentum factor (recent publication acceleration). Compounds with high scores represent mechanistically relevant, under-researched candidates with active research interest.

Key targets in this domain include: MTOR, PRKAA1, PRKAA2, IGF1, IGF1R, MSTN. The analysis covers 442 compounds from the BiohacksAI corpus of 4,824 substances derived from PubMed-indexed bioassay data.