What compounds affect the Nuclear signaling by ERBB4 pathway?

368 compounds in the BiohacksAI corpus have documented interactions with genes in the Nuclear signaling by ERBB4 pathway (Reactome ID: R-HSA-1251985). These compounds target 15 genes within this pathway.

What genes are in the Nuclear signaling by ERBB4 pathway?

The Nuclear signaling by ERBB4 pathway involves 15 genes. Key genes include: ADAM17, APH1A, APH1B, ERBB4, ESR1, NCOR1, NCSTN, PGR, PSEN1, PSEN2.

Nuclear signaling by ERBB4

REACTOME PATHWAY

Reactome: R-HSA-125198515 genes368 compounds

The Nuclear signaling by ERBB4 pathway (Reactome ID: R-HSA-1251985) involves 15 genes and is affected by 368 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM17 APH1A APH1B ERBB4 ESR1 NCOR1 NCSTN PGR PSEN1 PSEN2 PSENEN S100B SRC STAT5A YAP1

Compounds Affecting Nuclear signaling by ERBB4

#	Compound	Targets Hit	Studies
1	Dihydroergocristine	—	187
2	Resveratrol	—	298
3	Dasatinib	—	299
4	Genistein	—	300
5	Kaempferols	—	300
6	Dactinomycin	—	297
7	Rotenone	—	300
8	cycloheximide	—	300
9	Niclosamide	—	299
10	Quercetin	—	300
11	Daunorubicin	—	298
12	Emetine	—	298
13	Bisphenol A-Glycidyl Methacrylate	—	197
14	Levonorgestrel	—	292
15	Norgestrel	—	300
16	Ethinyl Estradiol	—	300
17	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
18	Methyltestosterone	—	300
19	Dehydroepiandrosterone	—	300
20	Dehydroepiandrosterone	—	300
21	Fulvestrant	—	295
22	Danazol	—	298
23	Estrone	—	300
24	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
25	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	Dihydrotestosterone	—	300
28	Ethidium	—	300
29	Ethynodiol Diacetate	—	300
30	Flutamide	—	298
31	Colchicine	—	300
32	Estriol	—	300
33	Mestranol	—	300
34	Norethindrone	—	300
35	Oxymetholone	—	298
36	Testosterone Propionate	—	300
37	Gestrinone	—	221
38	Hexachlorophene	—	300
39	Lynestrenol	—	299
40	Phenoxybenzamine	—	21
41	Pueraria	—	300
42	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
43	Progesterone	—	299
44	Bortezomib	—	300
45	Triiodothyronine	—	300
46	vinblastine sulfate	—	81
47	Celecoxib	—	295
48	Equilin	—	216
49	Loratadine	—	296
50	Methylcholanthrene	—	300

About the Nuclear signaling by ERBB4 Pathway

The Nuclear signaling by ERBB4 pathway is catalogued in Reactome (ID: R-HSA-1251985) and involves 15 genes. In the BiohacksAI corpus, 368 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, APH1A, APH1B, ERBB4, ESR1.