What compounds affect the Methylation pathway?

262 compounds in the BiohacksAI corpus have documented interactions with genes in the Methylation pathway (Reactome ID: R-HSA-156581). These compounds target 4 genes within this pathway.

What genes are in the Methylation pathway?

The Methylation pathway involves 4 genes. Key genes include: AHCY, CYP1A2, GSTO1, NNMT.

Methylation

REACTOME PATHWAY

Reactome: R-HSA-1565814 genes262 compounds

The Methylation pathway (Reactome ID: R-HSA-156581) involves 4 genes and is affected by 262 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AHCY CYP1A2 GSTO1 NNMT

Compounds Affecting Methylation

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Quercetin	—	300
3	Disulfiram	—	297
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Vitamin K 3	—	300
7	tyrphostin ag 1478	—	4
8	Methylene Blue	—	200
9	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
10	Chlorhexidine	—	299
11	Iodoacetamide	—	300
12	Aurintricarboxylic Acid	—	184
13	Cisplatin	—	300
14	Dequalinium	—	136
15	Edaravone	—	298
16	Guanabenz	—	298
17	propionylpromazine hydrochloride	—	2
18	Suramin	—	300
19	tyrphostin 9	—	2
20	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
21	Calcimycin	—	216
22	Phenacetin	—	300
23	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
24	Melatonin	—	297
25	chrysin	—	300
26	Flutamide	—	298
27	Genistein	—	300
28	Kaempferols	—	300
29	Clotrimazole	—	296
30	Methoxsalen	—	300
31	Piribedil	—	300
32	Riluzole	—	298
33	Sulindac	—	297
34	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
35	Pueraria	—	300
36	Isoniazid Antibacterial agent used primarily as	—	299
37	Leflunomide	—	297
38	Nocodazole Nocodazole is	—	215
39	Clofibrate	—	299
40	Diuron	—	300
41	Ethoxyquin Antioxidant; also	—	180
42	Secologanin Tryptamine Alkaloids Compounds formed by condensation of secologanin with tryptamine resulting in	—	300
43	Miconazole	—	298
44	Niclosamide	—	299
45	Perphenazine	—	297
46	Quipazine	—	300
47	Tolazamide	—	169
48	Fenofibrate	—	297
49	propyl gallate	—	261
50	Anastrozole	—	298

About the Methylation Pathway

The Methylation pathway is catalogued in Reactome (ID: R-HSA-156581) and involves 4 genes. In the BiohacksAI corpus, 262 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AHCY, CYP1A2, GSTO1, NNMT.