What compounds affect the Heme degradation pathway?

98 compounds in the BiohacksAI corpus have documented interactions with genes in the Heme degradation pathway (Reactome ID: R-HSA-189483). These compounds target 11 genes within this pathway.

What genes are in the Heme degradation pathway?

The Heme degradation pathway involves 11 genes. Key genes include: ABCC1, ABCC2, ABCG2, ALB, BLVRA, BLVRB, SLCO1B1, SLCO1B3, SLCO2B1, UGT1A1.

Heme degradation

REACTOME PATHWAY

Reactome: R-HSA-18948311 genes98 compounds

The Heme degradation pathway (Reactome ID: R-HSA-189483) involves 11 genes and is affected by 98 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCC2 ABCG2 ALB BLVRA BLVRB SLCO1B1 SLCO1B3 SLCO2B1 UGT1A1 UGT1A4

Compounds Affecting Heme degradation

#	Compound	Targets Hit	Studies
1	Olmesartan Medoxomil	—	300
2	Ritonavir	—	298
3	Atorvastatin	—	1,000
4	Genistein	—	300
5	Antimycin	—	300
6	Delavirdine	—	296
7	Gemfibrozil	—	297
8	Glyburide	—	298
9	Bilirubin	—	296
10	Rifamycins	—	300
11	Rifamycins	—	300
12	candesartan cilexetil [Supplementary Concept]	—	300
13	Silymarin	—	10
14	Quercetin	—	300
15	Abacavir	—	295
16	Emtricitabine	—	292
17	Lamivudine	—	299
18	Rimonabant	—	300
19	Trazodone	—	297
20	Pravastatin	—	297
21	Arachidonic Acid	—	245
22	Losartan	—	1,000
23	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
24	beta Carotene	—	299
25	Mometasone Furoate	—	292
26	Thyroxine	—	994
27	Sirolimus	—	300
28	Taurocholic Acid	—	300
29	Thyroxine	—	300
30	Triiodothyronine	—	300
31	licochalcone	—	267
32	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
33	Kaempferols	—	300
34	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
35	Daunorubicin	—	298
36	Febuxostat	—	297
37	scutellarein	—	113
38	Bosentan	—	298
39	Fusidic Acid	—	300
40	Leukotriene D4	—	300
41	Troglitazone	—	299
42	Bumetanide	—	299
43	cefaclor	—	299
44	cefadroxil	—	299
45	Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as	—	300
46	Cefmetazole	—	300
47	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
48	Cefoxitin	—	300
49	Ceftriaxone	—	299
50	cefuroxime	—	299

About the Heme degradation Pathway

The Heme degradation pathway is catalogued in Reactome (ID: R-HSA-189483) and involves 11 genes. In the BiohacksAI corpus, 98 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCC2, ABCG2, ALB, BLVRA.