What genes are in the SLC-mediated transport of neurotransmitters pathway?

The SLC-mediated transport of neurotransmitters pathway involves 8 genes. Key genes include: SLC22A1, SLC6A11, SLC6A15, SLC6A2, SLC6A3, SLC6A4, SLC6A5, SLC6A9.

SLC-mediated transport of neurotransmitters

Q: What compounds affect the SLC-mediated transport of neurotransmitters pathway?

127 compounds in the BiohacksAI corpus have documented interactions with genes in the SLC-mediated transport of neurotransmitters pathway (Reactome ID: R-HSA-442660). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4426608 genes127 compounds

The SLC-mediated transport of neurotransmitters pathway (Reactome ID: R-HSA-442660) involves 8 genes and is affected by 127 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SLC22A1 SLC6A11 SLC6A15 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9

Compounds Affecting SLC-mediated transport of neurotransmitters

#	Compound	Targets Hit	Studies
1	Carvedilol	—	296
2	Chlorhexidine	—	299
3	Duloxetine Hydrochloride	—	993
4	Fluoxetine	—	1,000
5	Sertraline	—	1,000
6	Venlafaxine Hydrochloride	—	1,000
7	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
8	Aripiprazole	—	298
9	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
10	Ethinyl Estradiol	—	300
11	Amoxapine	—	259
12	Astemizole Antihistamine drug now withdrawn from	—	280
13	Benzydamine	—	298
14	Chlorpheniramine	—	298
15	cinacalcet	—	298
16	Cinnarizine	—	299
17	Crizotinib	—	298
18	Dequalinium	—	136
19	Flunarizine Flunarizine is	—	299
20	Fluspirilene	—	74
21	lidoflazine	—	278
22	Metergoline	—	144
23	Nebivolol	—	297
24	Nefopam Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for	—	299
25	Nortriptyline	—	295
26	oxatomide [Supplementary Concept] structure;	—	128
27	Oxyfedrine	—	144
28	pentamidine	—	299
29	Phenelzine	—	297
30	Quinidine	—	298
31	Thiethylperazine	—	165
32	Amlodipine	—	1,000
33	Cabergoline	—	299
34	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	—	995
35	Simvastatin	—	1,000
36	Caspofungin	—	299
37	Celecoxib	—	295
38	Cetirizine	—	296
39	Estrone	—	300
40	Fluvoxamine	—	297
41	Hexachlorophene	—	300
42	Labetalol	—	295
43	Leflunomide	—	297
44	Loratadine	—	296
45	Maprotiline	—	299
46	Meclizine	—	121
47	Perphenazine	—	297
48	Reboxetine	—	298
49	Troglitazone	—	299
50	Venlafaxine Hydrochloride	—	122

About the SLC-mediated transport of neurotransmitters Pathway

The SLC-mediated transport of neurotransmitters pathway is catalogued in Reactome (ID: R-HSA-442660) and involves 8 genes. In the BiohacksAI corpus, 127 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SLC22A1, SLC6A11, SLC6A15, SLC6A2, SLC6A3.