What compounds affect the SLC transporter disorders pathway?

161 compounds in the BiohacksAI corpus have documented interactions with genes in the SLC transporter disorders pathway (Reactome ID: R-HSA-5619102). These compounds target 26 genes within this pathway.

What genes are in the SLC transporter disorders pathway?

The SLC transporter disorders pathway involves 26 genes. Key genes include: AVPR1A, AVPR1B, AVPR2, GCK, GCKR, SLC12A1, SLC12A3, SLC17A5, SLC1A1, SLC1A3.

SLC transporter disorders

REACTOME PATHWAY

Reactome: R-HSA-561910226 genes161 compounds

The SLC transporter disorders pathway (Reactome ID: R-HSA-5619102) involves 26 genes and is affected by 161 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AVPR1A AVPR1B AVPR2 GCK GCKR SLC12A1 SLC12A3 SLC17A5 SLC1A1 SLC1A3 SLC22A12 SLC22A5 SLC24A4 SLC26A4 SLC2A1 SLC2A2 SLC2A9 SLC34A2 SLC5A1 SLC5A2 SLC5A7 SLC6A2 SLC6A3 SLC6A5 SLCO1B1 SLCO1B3

Compounds Affecting SLC transporter disorders

#	Compound	Targets Hit	Studies
1	Sertraline	—	1,000
2	Aripiprazole	—	298
3	Simvastatin	—	1,000
4	Astemizole Antihistamine drug now withdrawn from	—	280
5	Canagliflozin	—	295
6	Chlorhexidine	—	299
7	Crizotinib	—	298
8	Hexachlorophene	—	300
9	Ritonavir	—	298
10	Genistein	—	300
11	Arginine Vasopressin	—	298
12	Oxytocin	—	299
13	Deamino Arginine Vasopressin	—	46
14	Ornipressin	—	82
15	Lypressin	—	24
16	Duloxetine Hydrochloride	—	993
17	Fluoxetine	—	1,000
18	Venlafaxine Hydrochloride	—	1,000
19	Digoxin	—	299
20	Amlodipine	—	1,000
21	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
22	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
23	Cabergoline	—	299
24	Ethinyl Estradiol	—	300
25	Amoxapine	—	259
26	Benzydamine	—	298
27	Carvedilol	—	296
28	Caspofungin	—	299
29	Chlorpheniramine	—	298
30	cinacalcet	—	298
31	Cinnarizine	—	299
32	Dequalinium	—	136
33	Flunarizine Flunarizine is	—	299
34	Fluspirilene	—	74
35	Labetalol	—	295
36	Leflunomide	—	297
37	lidoflazine	—	278
38	Maprotiline	—	299
39	Meclizine	—	121
40	Metergoline	—	144
41	Nebivolol	—	297
42	Nefopam Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for	—	299
43	Nortriptyline	—	295
44	oxatomide [Supplementary Concept] structure;	—	128
45	Oxyfedrine	—	144
46	pentamidine	—	299
47	Phenelzine	—	297
48	Reboxetine	—	298
49	Thiethylperazine	—	165
50	Troglitazone	—	299

About the SLC transporter disorders Pathway

The SLC transporter disorders pathway is catalogued in Reactome (ID: R-HSA-5619102) and involves 26 genes. In the BiohacksAI corpus, 161 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AVPR1A, AVPR1B, AVPR2, GCK, GCKR.