What compounds affect the Neutrophil degranulation pathway?

259 compounds in the BiohacksAI corpus have documented interactions with genes in the Neutrophil degranulation pathway (Reactome ID: R-HSA-6798695). These compounds target 99 genes within this pathway.

What genes are in the Neutrophil degranulation pathway?

The Neutrophil degranulation pathway involves 99 genes. Key genes include: ADAM10, AGL, ALOX5, AMPD3, ANXA2, AOC1, ARSA, CAPN1, CCT2, CD47.

Neutrophil degranulation

REACTOME PATHWAY

Reactome: R-HSA-679869599 genes259 compounds

The Neutrophil degranulation pathway (Reactome ID: R-HSA-6798695) involves 99 genes and is affected by 259 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 AGL ALOX5 AMPD3 ANXA2 AOC1 ARSA CAPN1 CCT2 CD47 CDA CDK13 CSNK2B CTSA CTSG CXCR1 CYBB EEF2 ELANE FABP5 FGR FPR1 FPR2 FRK GAA GALNS GLA GPR84 GSDMD GSTP1+69 more

Compounds Affecting Neutrophil degranulation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	Hexachlorophene	—	300
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	Sorafenib	—	300
8	celastrol	—	300
9	Idarubicin	—	299
10	egcg	—	300
11	Kaempferols	—	300
12	Clotrimazole	—	296
13	piceatannol	—	300
14	Reserpine	—	297
15	Calcimycin	—	216
16	cycloheximide	—	300
17	withaferin	—	300
18	Disulfiram	—	297
19	Crizotinib	—	298
20	Resveratrol	—	298
21	tyrphostin ag 1478	—	4
22	caffeic acid	—	300
23	Masoprocol	—	300
24	fisetin	—	78
25	Dasatinib	—	299
26	Adenosine Triphosphate	—	300
27	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
28	Lovastatin	—	300
29	2-Chloroadenosine 2-Chloroadenosine.	—	300
30	Azacitidine	—	298
31	Azacitidine	—	300
32	Digitoxin	—	300
33	Digoxin	—	299
34	Miconazole	—	298
35	streptonigrin	—	299
36	vinblastine sulfate	—	81
37	Genistein	—	300
38	Phenylbutazone	—	300
39	triolimus [Supplementary Concept]	—	33
40	Podophyllotoxin	—	14
41	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
42	Afatinib	—	297
43	1-Deoxynojirimycin	—	299
44	Histidine	—	158
45	Myristic Acid	—	300
46	Ergosterol	—	300
47	Methylene Blue	—	200
48	Sertraline	—	1,000
49	Methotrexate	—	289
50	Anisomycin	—	247

About the Neutrophil degranulation Pathway

The Neutrophil degranulation pathway is catalogued in Reactome (ID: R-HSA-6798695) and involves 99 genes. In the BiohacksAI corpus, 259 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, AGL, ALOX5, AMPD3, ANXA2.