Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Q: What compounds affect the Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors pathway?

279 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors pathway (Reactome ID: R-HSA-8864260). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-886426011 genes279 compounds

The Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors pathway (Reactome ID: R-HSA-8864260) involves 11 genes and is affected by 279 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EGFR EP300 ERBB2 ESR1 HSPD1 KDM5B KIT MYC NPM1 SUMO1

Compounds Affecting Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Hexachlorophene	—	300
3	Danazol	—	298
4	Colchicine	—	300
5	Adapalene	—	296
6	Axitinib	—	298
7	rafoxanide	—	172
8	Aurintricarboxylic Acid	—	184
9	egcg	—	300
10	plumbagin [Supplementary Concept]	—	300
11	Crizotinib	—	298
12	Afatinib	—	297
13	tyrphostin ag 1478	—	4
14	Levonorgestrel	—	292
15	Norgestrel	—	300
16	Resveratrol	—	298
17	Ethinyl Estradiol	—	300
18	Genistein	—	300
19	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
20	Methyltestosterone	—	300
21	Dehydroepiandrosterone	—	300
22	Dehydroepiandrosterone	—	300
23	Fulvestrant	—	295
24	Kaempferols	—	300
25	Dactinomycin	—	297
26	Estrone	—	300
27	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
28	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
29	Rotenone	—	300
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	Dihydrotestosterone	—	300
32	Ethidium	—	300
33	Ethynodiol Diacetate	—	300
34	Flutamide	—	298
35	Reserpine	—	297
36	Estriol	—	300
37	Mestranol	—	300
38	Norethindrone	—	300
39	Oxymetholone	—	298
40	Testosterone Propionate	—	300
41	cycloheximide	—	300
42	Gestrinone	—	221
43	Lynestrenol	—	299
44	Phenoxybenzamine	—	21
45	Pueraria	—	300
46	Digoxin	—	299
47	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
48	Progesterone	—	299
49	Vitamin	—	295
50	Bortezomib	—	300

About the Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Pathway

The Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors pathway is catalogued in Reactome (ID: R-HSA-8864260) and involves 11 genes. In the BiohacksAI corpus, 279 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EGFR, EP300, ERBB2, ESR1.