TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

Q: What compounds affect the TFAP2 (AP-2) family regulates transcription of growth factors and their receptors pathway?

264 compounds in the BiohacksAI corpus have documented interactions with genes in the TFAP2 (AP-2) family regulates transcription of growth factors and their receptors pathway (Reactome ID: R-HSA-8866910). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-88669104 genes264 compounds

The TFAP2 (AP-2) family regulates transcription of growth factors and their receptors pathway (Reactome ID: R-HSA-8866910) involves 4 genes and is affected by 264 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EGFR ERBB2 ESR1 KIT

Compounds Affecting TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Axitinib	—	298
3	Afatinib	—	297
4	tyrphostin ag 1478	—	4
5	Levonorgestrel	—	292
6	Norgestrel	—	300
7	Resveratrol	—	298
8	Ethinyl Estradiol	—	300
9	Genistein	—	300
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
11	Methyltestosterone	—	300
12	Dehydroepiandrosterone	—	300
13	Dehydroepiandrosterone	—	300
14	Fulvestrant	—	295
15	Kaempferols	—	300
16	Dactinomycin	—	297
17	Danazol	—	298
18	Estrone	—	300
19	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
20	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
21	Rotenone	—	300
22	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
23	Dihydrotestosterone	—	300
24	Ethidium	—	300
25	Ethynodiol Diacetate	—	300
26	Flutamide	—	298
27	Reserpine	—	297
28	Colchicine	—	300
29	Estriol	—	300
30	Mestranol	—	300
31	Norethindrone	—	300
32	Oxymetholone	—	298
33	Testosterone Propionate	—	300
34	cycloheximide	—	300
35	Gestrinone	—	221
36	Hexachlorophene	—	300
37	Lynestrenol	—	299
38	Phenoxybenzamine	—	21
39	Pueraria	—	300
40	Digoxin	—	299
41	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
42	Progesterone	—	299
43	Vitamin	—	295
44	Bortezomib	—	300
45	mg624	—	3
46	Trabectedin	—	297
47	propyl gallate	—	261
48	Niclosamide	—	299
49	Triiodothyronine	—	300
50	vinblastine sulfate	—	81

About the TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Pathway

The TFAP2 (AP-2) family regulates transcription of growth factors and their receptors pathway is catalogued in Reactome (ID: R-HSA-8866910) and involves 4 genes. In the BiohacksAI corpus, 264 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EGFR, ERBB2, ESR1, KIT.