RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Q: What compounds affect the RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) pathway?

93 compounds in the BiohacksAI corpus have documented interactions with genes in the RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) pathway (Reactome ID: R-HSA-8877330). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-88773303 genes93 compounds

The RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) pathway (Reactome ID: R-HSA-8877330) involves 3 genes and is affected by 93 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CBFB IFNG RUNX1

Compounds Affecting RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Aurintricarboxylic Acid	—	184
3	Dihydroxyphenylalanine	—	300
4	Disulfiram	—	297
5	Ethidium	—	300
6	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
7	Fusaric Acid	—	300
8	Harmaline	—	300
9	Dacarbazine	—	299
10	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
11	2-Methoxyestradiol	—	300
12	Hexachlorophene	—	300
13	Anisomycin	—	247
14	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
15	Bortezomib	—	300
16	Camptothecin	—	300
17	cycloheximide	—	300
18	Dasatinib	—	299
19	Desoxycorticosterone Acetate	—	300
20	tyrphostin 9	—	2
21	Quercetin	—	300
22	Azathioprine	—	300
23	Crizotinib	—	298
24	Econazole	—	299
25	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
26	Nocodazole Nocodazole is	—	215
27	Sorafenib	—	300
28	Ursolic Acid	—	300
29	Afatinib	—	297
30	alsterpaullone	—	12
31	Chlorhexidine	—	299
32	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
33	Clofarabine	—	298
34	Clotrimazole	—	296
35	Dactinomycin	—	297
36	darapladib [Supplementary Concept]	—	44
37	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
38	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
39	Epirubicin	—	300
40	Estrone	—	300
41	Ethinyl Estradiol	—	300
42	Fulvestrant	—	295
43	Idarubicin	—	299
44	Irinotecan	—	298
45	Levonorgestrel	—	292
46	Miconazole	—	298
47	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
48	Niclosamide	—	299
49	Norgestrel	—	300
50	Novobiocin	—	300

About the RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Pathway

The RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) pathway is catalogued in Reactome (ID: R-HSA-8877330) and involves 3 genes. In the BiohacksAI corpus, 93 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CBFB, IFNG, RUNX1.