RUNX1 regulates transcription of genes involved in WNT signaling

Q: What compounds affect the RUNX1 regulates transcription of genes involved in WNT signaling pathway?

257 compounds in the BiohacksAI corpus have documented interactions with genes in the RUNX1 regulates transcription of genes involved in WNT signaling pathway (Reactome ID: R-HSA-8939256). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-89392563 genes257 compounds

The RUNX1 regulates transcription of genes involved in WNT signaling pathway (Reactome ID: R-HSA-8939256) involves 3 genes and is affected by 257 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CBFB ESR1 RUNX1

Compounds Affecting RUNX1 regulates transcription of genes involved in WNT signaling

#	Compound	Targets Hit	Studies
1	Ethidium	—	300
2	Daunorubicin	—	298
3	Disulfiram	—	297
4	Aurintricarboxylic Acid	—	184
5	Dihydroxyphenylalanine	—	300
6	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
7	Fusaric Acid	—	300
8	Harmaline	—	300
9	Levonorgestrel	—	292
10	Norgestrel	—	300
11	Resveratrol	—	298
12	Ethinyl Estradiol	—	300
13	Genistein	—	300
14	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
15	Methyltestosterone	—	300
16	Dehydroepiandrosterone	—	300
17	Dehydroepiandrosterone	—	300
18	Fulvestrant	—	295
19	Kaempferols	—	300
20	Dactinomycin	—	297
21	Danazol	—	298
22	Estrone	—	300
23	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
24	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
25	Rotenone	—	300
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	Dihydrotestosterone	—	300
28	Ethynodiol Diacetate	—	300
29	Flutamide	—	298
30	Reserpine	—	297
31	Colchicine	—	300
32	Estriol	—	300
33	Mestranol	—	300
34	Norethindrone	—	300
35	Oxymetholone	—	298
36	Testosterone Propionate	—	300
37	cycloheximide	—	300
38	Gestrinone	—	221
39	Hexachlorophene	—	300
40	Lynestrenol	—	299
41	Phenoxybenzamine	—	21
42	Pueraria	—	300
43	Digoxin	—	299
44	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
45	Progesterone	—	299
46	Vitamin	—	295
47	Bortezomib	—	300
48	mg624	—	3
49	Trabectedin	—	297
50	propyl gallate	—	261

About the RUNX1 regulates transcription of genes involved in WNT signaling Pathway

The RUNX1 regulates transcription of genes involved in WNT signaling pathway is catalogued in Reactome (ID: R-HSA-8939256) and involves 3 genes. In the BiohacksAI corpus, 257 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CBFB, ESR1, RUNX1.