What compounds affect the Interleukin-37 signaling pathway?

84 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-37 signaling pathway (Reactome ID: R-HSA-9008059). These compounds target 9 genes within this pathway.

What genes are in the Interleukin-37 signaling pathway?

The Interleukin-37 signaling pathway involves 9 genes. Key genes include: CASP1, PTPN14, PTPN2, PTPN5, PTPN6, PTPN7, SMAD3, STAT3, TBK1.

Interleukin-37 signaling

REACTOME PATHWAY

Reactome: R-HSA-90080599 genes84 compounds

The Interleukin-37 signaling pathway (Reactome ID: R-HSA-9008059) involves 9 genes and is affected by 84 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP1 PTPN14 PTPN2 PTPN5 PTPN6 PTPN7 SMAD3 STAT3 TBK1

Compounds Affecting Interleukin-37 signaling

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Celecoxib	—	295
3	Ethinyl Estradiol	—	300
4	Hexachlorophene	—	300
5	celastrol	—	300
6	Calcimycin	—	216
7	cycloheximide	—	300
8	alsterpaullone	—	12
9	Anisomycin	—	247
10	Azacitidine	—	298
11	Azacitidine	—	300
12	kenpaullone	—	8
13	Nisoldipine	—	297
14	Tubercidin	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Kaempferols	—	300
17	Quercetin	—	300
18	cardamonin	—	180
19	Colchicine	—	300
20	Dactinomycin	—	297
21	Danazol	—	298
22	Dasatinib	—	299
23	Dinitrochlorobenzene	—	300
24	Ethidium	—	300
25	Flutamide	—	298
26	Loratadine	—	296
27	Oxyphenbutazone	—	300
28	Podophyllotoxin	—	14
29	vinblastine sulfate	—	81
30	Vincristine	—	299
31	chrysin	—	300
32	egcg	—	300
33	Fluoxetine	—	1,000
34	Methylene Blue	—	200
35	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
36	Astemizole Antihistamine drug now withdrawn from	—	280
37	Bortezomib	—	300
38	Ciclopirox	—	88
39	Cladribine	—	297
40	Daunorubicin	—	298
41	Digitoxin	—	300
42	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
43	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
44	Domperidone	—	299
45	Emetine	—	298
46	Equilin	—	216
47	Ezetimibe	—	296
48	Fluspirilene	—	74
49	Idazoxan	—	300
50	Lynestrenol	—	299

About the Interleukin-37 signaling Pathway

The Interleukin-37 signaling pathway is catalogued in Reactome (ID: R-HSA-9008059) and involves 9 genes. In the BiohacksAI corpus, 84 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP1, PTPN14, PTPN2, PTPN5, PTPN6.