What compounds affect the IFNG signaling activates MAPKs pathway?

109 compounds in the BiohacksAI corpus have documented interactions with genes in the IFNG signaling activates MAPKs pathway (Reactome ID: R-HSA-9732724). These compounds target 5 genes within this pathway.

What genes are in the IFNG signaling activates MAPKs pathway?

The IFNG signaling activates MAPKs pathway involves 5 genes. Key genes include: IFNG, JAK2, MAPK1, MAPK3, RAF1.

IFNG signaling activates MAPKs

REACTOME PATHWAY

Reactome: R-HSA-97327245 genes109 compounds

The IFNG signaling activates MAPKs pathway (Reactome ID: R-HSA-9732724) involves 5 genes and is affected by 109 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IFNG JAK2 MAPK1 MAPK3 RAF1

Compounds Affecting IFNG signaling activates MAPKs

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	alsterpaullone	—	12
4	2-Methoxyestradiol	—	300
5	Camptothecin	—	300
6	Azathioprine	—	300
7	Clotrimazole	—	296
8	Podophyllotoxin	—	14
9	Tripterygium	—	300
10	Vemurafenib	—	298
11	Progesterone	—	299
12	Astemizole Antihistamine drug now withdrawn from	—	280
13	Cladribine	—	297
14	sp600125	—	117
15	Trifluridine	—	295
16	plumbagin [Supplementary Concept]	—	300
17	pd98059	—	7
18	kenpaullone	—	8
19	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
20	trametinib	—	296
21	withaferin	—	300
22	Dacarbazine	—	299
23	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
24	Hexachlorophene	—	300
25	Anisomycin	—	247
26	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
27	Bortezomib	—	300
28	cycloheximide	—	300
29	Desoxycorticosterone Acetate	—	300
30	tyrphostin 9	—	2
31	Quercetin	—	300
32	Crizotinib	—	298
33	Econazole	—	299
34	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
35	Nocodazole Nocodazole is	—	215
36	Ursolic Acid	—	300
37	Afatinib	—	297
38	Chlorhexidine	—	299
39	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
40	Clofarabine	—	298
41	Dactinomycin	—	297
42	darapladib [Supplementary Concept]	—	44
43	Daunorubicin	—	298
44	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
45	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
46	Epirubicin	—	300
47	Estrone	—	300
48	Ethinyl Estradiol	—	300
49	Fulvestrant	—	295
50	Idarubicin	—	299

About the IFNG signaling activates MAPKs Pathway

The IFNG signaling activates MAPKs pathway is catalogued in Reactome (ID: R-HSA-9732724) and involves 5 genes. In the BiohacksAI corpus, 109 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IFNG, JAK2, MAPK1, MAPK3, RAF1.