What genes are in the NFE2L2 regulating ER-stress associated genes pathway?

The NFE2L2 regulating ER-stress associated genes pathway involves 3 genes. Key genes include: CREBBP, EP300, NFE2L2.

NFE2L2 regulating ER-stress associated genes

Q: What compounds affect the NFE2L2 regulating ER-stress associated genes pathway?

206 compounds in the BiohacksAI corpus have documented interactions with genes in the NFE2L2 regulating ER-stress associated genes pathway (Reactome ID: R-HSA-9818035). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98180353 genes206 compounds

The NFE2L2 regulating ER-stress associated genes pathway (Reactome ID: R-HSA-9818035) involves 3 genes and is affected by 206 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 NFE2L2

Compounds Affecting NFE2L2 regulating ER-stress associated genes

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Papaverine	—	299
4	Resveratrol	—	298
5	Vitamin	—	295
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Genistein	—	300
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	alpha-Linolenic Acid	—	300
11	Oxymetholone	—	298
12	Rotenone	—	300
13	Methylene Blue	—	200
14	Ethoxyquin Antioxidant; also	—	180
15	Nitrofurazone	—	300
16	Quercetin	—	300
17	Azathioprine	—	300
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	Mestranol	—	300
20	methoprene	—	300
21	Niclosamide	—	299
22	Phenelzine	—	2
23	vinblastine sulfate	—	81
24	chrysin	—	300
25	alyssin [Supplementary Concept]	—	300
26	Digitoxin	—	300
27	Digoxin	—	299
28	Flutamide	—	298
29	Hexachlorophene	—	300
30	Linoleic Acid	—	300
31	Vitamin K 3	—	300
32	Nitrofurantoin	—	297
33	Ouabain	—	300
34	Podophyllotoxin	—	14
35	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
36	Toxaphene	—	299
37	DEAD-box RNA Helicases	—	169
38	Thioctic Acid	—	298
39	amlexanox	—	96
40	Bortezomib	—	300
41	Chlormadinone Acetate	—	300
42	Ethidium	—	300
43	Feprazone	—	63
44	Idazoxan	—	300
45	Leflunomide	—	297
46	Oxyphenbutazone	—	300
47	Thioctic Acid	—	300
48	Caffeine	—	299
49	propyl gallate	—	261
50	Ascorbic Acid	—	299

About the NFE2L2 regulating ER-stress associated genes Pathway

The NFE2L2 regulating ER-stress associated genes pathway is catalogued in Reactome (ID: R-HSA-9818035) and involves 3 genes. In the BiohacksAI corpus, 206 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, NFE2L2.