What genes are in the Developmental Lineages of the Mammary Gland pathway?

The Developmental Lineages of the Mammary Gland pathway involves 8 genes. Key genes include: ALDH1A1, EGFR, ERBB2, ESR1, KIT, MME, MUC1, PGR.

Developmental Lineages of the Mammary Gland

Q: What compounds affect the Developmental Lineages of the Mammary Gland pathway?

342 compounds in the BiohacksAI corpus have documented interactions with genes in the Developmental Lineages of the Mammary Gland pathway (Reactome ID: R-HSA-9924644). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-99246448 genes342 compounds

The Developmental Lineages of the Mammary Gland pathway (Reactome ID: R-HSA-9924644) involves 8 genes and is affected by 342 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALDH1A1 EGFR ERBB2 ESR1 KIT MME MUC1 PGR

Compounds Affecting Developmental Lineages of the Mammary Gland

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Axitinib	—	298
4	Disulfiram	—	297
5	Levonorgestrel	—	292
6	Norgestrel	—	300
7	Resveratrol	—	298
8	Ethinyl Estradiol	—	300
9	Genistein	—	300
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
11	Methyltestosterone	—	300
12	Dehydroepiandrosterone	—	300
13	Dehydroepiandrosterone	—	300
14	Fulvestrant	—	295
15	Kaempferols	—	300
16	Dactinomycin	—	297
17	Danazol	—	298
18	Estrone	—	300
19	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
20	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
21	Rotenone	—	300
22	Dihydrotestosterone	—	300
23	Ethidium	—	300
24	Ethynodiol Diacetate	—	300
25	Flutamide	—	298
26	Estriol	—	300
27	Mestranol	—	300
28	Norethindrone	—	300
29	Oxymetholone	—	298
30	Testosterone Propionate	—	300
31	cycloheximide	—	300
32	Gestrinone	—	221
33	Hexachlorophene	—	300
34	Lynestrenol	—	299
35	Phenoxybenzamine	—	21
36	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
37	Progesterone	—	299
38	Bortezomib	—	300
39	Niclosamide	—	299
40	Triiodothyronine	—	300
41	vinblastine sulfate	—	81
42	Celecoxib	—	295
43	Equilin	—	216
44	Loratadine	—	296
45	Methylcholanthrene	—	300
46	Masoprocol	—	300
47	Pregnenolone	—	300
48	Quinestrol	—	194
49	Quercetin	—	300
50	Adapalene	—	296

About the Developmental Lineages of the Mammary Gland Pathway

The Developmental Lineages of the Mammary Gland pathway is catalogued in Reactome (ID: R-HSA-9924644) and involves 8 genes. In the BiohacksAI corpus, 342 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALDH1A1, EGFR, ERBB2, ESR1, KIT.