What compounds target 5-HYDROXYTRYPTAMINE?

BiohacksAI has identified 122 compounds that interact with 5-HYDROXYTRYPTAMINE (5-hydroxytryptamine receptor 2A (human)). Top compounds include: Aripiprazole, Buspirone, Mianserin, Quetiapine Fumarate, Methysergide. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

5-HYDROXYTRYPTAMINE

Q: What is 5-HYDROXYTRYPTAMINE (5-hydroxytryptamine receptor 2A)?

5-HYDROXYTRYPTAMINE is 5-hydroxytryptamine receptor 2A (human). It is a molecular target for 122 compounds documented in PubMed bioassay data. UniProt ID: P28223.

MOLECULAR TARGET

5-hydroxytryptamine receptor 2A (human)

UniProt: P28223122 compounds

5-HYDROXYTRYPTAMINE (5-hydroxytryptamine receptor 2A (human)) is targeted by 122 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting 5-HYDROXYTRYPTAMINE

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Aripiprazole	4.11	60
2	Buspirone	4.04	56
3	Mianserin	3.58	35
4	Quetiapine Fumarate	3.37	28
5	Methysergide	3.14	22
6	Lisuride	3.09	21
7	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	3.04	20
8	Metergoline	3.00	19
9	Pergolide	3.00	19
10	Sumatriptan	3.00	19
11	Trazodone	3.00	19
12	Bromocriptine	2.94	18
13	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	2.89	17
14	Ergotamine	2.89	17
15	Cyproheptadine	2.77	15
16	Methylergonovine	2.77	15
17	Amoxapine	2.71	14
18	Carvedilol	2.71	14
19	Dihydroergotamine	2.71	14
20	Ergonovine	2.71	14
21	Nortriptyline	2.71	14
22	Astemizole Antihistamine drug now withdrawn from	2.64	13
23	Oxymetazoline	2.64	13
24	Promethazine	2.64	13
25	Propranolol	2.56	12
26	Yohimbine	2.56	12
27	Pindolol	2.40	10
28	Maprotiline	2.30	9
29	Miconazole	2.30	9
30	Sertraline	2.20	8
31	Domperidone	2.20	8
32	Flunarizine Flunarizine is	2.20	8
33	Guanabenz	2.20	8
34	Guanfacine	2.20	8
35	Econazole	2.08	7
36	Metoclopramide	2.08	7
37	Phentolamine	2.08	7
38	Cinnarizine	1.95	6
39	Cyclizine	1.95	6
40	Dimenhydrinate	1.95	6
41	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	1.95	6
42	Clotrimazole	1.79	5
43	Fenofibrate	1.79	5
44	Mescaline Hallucinogenic alkaloid isolated from	1.79	5
45	Quipazine	1.79	5
46	Vortioxetine	1.79	5
47	2-Acetylaminofluorene	1.61	4
48	2-Hydroxypropyl-beta-cyclodextrin Derivative of beta-cyclodextrin that is used as	1.61	4
49	Hexachlorophene	1.61	4
50	Labetalol	1.61	4

Showing top 50 of 122 compounds. Use the BiohacksAI search to explore all 5-HYDROXYTRYPTAMINE modulators.

About 5-HYDROXYTRYPTAMINE as a Drug Target

5-HYDROXYTRYPTAMINE (5-hydroxytryptamine receptor 2A (human)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 122 compounds with documented 5-HYDROXYTRYPTAMINE interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

5-HYDROXYTRYPTAMINE inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.