What compounds target AAK1?

BiohacksAI has identified 56 compounds that interact with AAK1 (AP2 associated kinase 1). Top compounds include: erlotinib, alvocidib, tozasertib, ruxolitinib, palbociclib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is AAK1 (AP2 associated kinase)?

AAK1 is AP2 associated kinase 1. It is a molecular target for 56 compounds documented in PubMed bioassay data. UniProt ID: Q2M2I8. NCBI Gene ID: 22848.

AAK1

MOLECULAR TARGET

AP2 associated kinase 1

UniProt: Q2M2I8 NCBI Gene: 2284856 compounds

AAK1 (AP2 associated kinase 1) is targeted by 56 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting AAK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	alvocidib	4.52	91
3	tozasertib	4.33	75
4	ruxolitinib	4.23	68
5	palbociclib	4.22	67
6	bosutinib	4.08	58
7	bi 2536	4.01	54
8	midostaurin	3.85	46
9	pazopanib	3.69	39
10	abemaciclib	3.66	38
11	nintedanib	3.61	36
12	baricitinib	3.56	34
13	pelitinib	3.50	32
14	tae 684	3.43	30
15	pexidartinib	3.43	30
16	fedratinib	3.40	29
17	gilteritinib	3.40	29
18	sp 600125	3.22	24
19	dovitinib	3.09	21
20	jnj 7706621	3.09	21
21	at 9283	3.09	21
22	upadacitinib	3.09	21
23	selumetinib	3.09	21
24	lestaurtinib	3.04	20
25	pacritinib	3.04	20
26	filgotinib	3.04	20
27	pf 03758309	3.00	19
28	ruboxistaurin	2.94	18
29	defosbarasertib	2.89	17
30	momelotinib	2.89	17
31	orantinib	2.89	17
32	r 406	2.83	16
33	k 252a	2.83	16
34	milciclib	2.77	15
35	pha 665752	2.71	14
36	azd 5438	2.71	14
37	kw 2449	2.64	13
38	azd 7762	2.30	9
39	su 014813	2.20	8
40	decernotinib	2.20	8
41	y 39983	2.20	8
42	cyc 116	2.08	7
43	enzastaurin	2.08	7
44	tg100 115	2.08	7
45	asp 3026	2.08	7
46	mk 2461	2.08	7
47	ravoxertinib	2.08	7
48	gsk 1059615	1.95	6
49	whi p131	1.95	6
50	pf 03814735	1.79	5

Showing top 50 of 56 compounds. Use the BiohacksAI search to explore all AAK1 modulators.

About AAK1 as a Drug Target

AAK1 (AP2 associated kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 56 compounds with documented AAK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

AAK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.