What compounds target ABCB11?

BiohacksAI has identified 47 compounds that interact with ABCB11 (ATP binding cassette subfamily B member 11). Top compounds include: Glyburide, Pioglitazone, Troglitazone, Ritonavir, Taurocholic Acid. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ABCB11 (ATP binding cassette)?

ABCB11 is ATP binding cassette subfamily B member 11. It is a molecular target for 47 compounds documented in PubMed bioassay data. UniProt ID: O95342. NCBI Gene ID: 8647.

ABCB11

MOLECULAR TARGET

ATP binding cassette subfamily B member 11

UniProt: O95342 NCBI Gene: 864747 compounds

ABCB11 (ATP binding cassette subfamily B member 11) is targeted by 47 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ABCB11

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Glyburide	2.40	10
2	Pioglitazone	2.20	8
3	Troglitazone	2.20	8
4	Ritonavir	1.79	5
5	Taurocholic Acid	1.79	5
6	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.61	4
7	Reserpine	1.61	4
8	Rifamycins	1.61	4
9	Rifamycins	1.61	4
10	Sorafenib	1.61	4
11	Losartan	1.39	3
12	Irbesartan	1.39	3
13	Taurochenodeoxycholic Acid	1.39	3
14	Valinomycin	1.39	3
15	Progesterone	1.10	2
16	Sirolimus	1.10	2
17	Clotrimazole	1.10	2
18	Glycochenodeoxycholic Acid	1.10	2
19	Simvastatin	0.69	1
20	Astemizole Antihistamine drug now withdrawn from	0.69	1
21	Axitinib	0.69	1
22	beta Carotene	0.69	1
23	Bromocriptine	0.69	1
24	Chenodeoxycholic Acid	0.69	1
25	Cholic Acid	0.69	1
26	Danazol	0.69	1
27	Dicloxacillin	0.69	1
28	Digitoxin	0.69	1
29	Disulfiram	0.69	1
30	Econazole	0.69	1
31	Ethinyl Estradiol	0.69	1
32	Everolimus	0.69	1
33	Flunarizine Flunarizine is	0.69	1
34	Fusidic Acid	0.69	1
35	Halcinonide	0.69	1
36	Megestrol Acetate Megestrol acetate is	0.69	1
37	Metergoline	0.69	1
38	Miconazole	0.69	1
39	Mometasone Furoate	0.69	1
40	Nisoldipine	0.69	1
41	Olmesartan Medoxomil	0.69	1
42	Papaverine	0.69	1
43	Penicillin G	0.69	1
44	Piperonyl Butoxide	0.69	1
45	Rimonabant	0.69	1
46	Rotenone	0.69	1
47	Ursodeoxycholic Acid	0.69	1

About ABCB11 as a Drug Target

ABCB11 (ATP binding cassette subfamily B member 11) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 47 compounds with documented ABCB11 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ABCB11 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.