What compounds target ABL2?

BiohacksAI has identified 57 compounds that interact with ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). Top compounds include: gefitinib, erlotinib, imatinib, ibrutinib, cabozantinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ABL2 (ABL proto-oncogene 2,)?

ABL2 is ABL proto-oncogene 2, non-receptor tyrosine kinase. It is a molecular target for 57 compounds documented in PubMed bioassay data. UniProt ID: P42684. NCBI Gene ID: 27.

ABL2

MOLECULAR TARGET

ABL proto-oncogene 2, non-receptor tyrosine kinase

UniProt: P42684 NCBI Gene: 2757 compounds

ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) is targeted by 57 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ABL2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	imatinib	5.47	236
4	ibrutinib	4.86	128
5	cabozantinib	4.39	80
6	foretinib	4.34	76
7	tozasertib	4.33	75
8	vandetanib	4.30	73
9	ponatinib	4.26	70
10	nilotinib	4.17	64
11	bosutinib	4.08	58
12	doramapimod	4.06	57
13	pazopanib	3.69	39
14	nintedanib	3.61	36
15	canertinib	3.53	33
16	pelitinib	3.50	32
17	tae 684	3.43	30
18	fedratinib	3.40	29
19	bms 777607	3.37	28
20	mln 8054	3.33	27
21	saracatinib	3.33	27
22	dabrafenib	3.30	26
23	neflamapimod	3.30	26
24	alisertib	3.30	26
25	dovitinib	3.09	21
26	at 9283	3.09	21
27	dasatinib anhydrous	3.09	21
28	lestaurtinib	3.04	20
29	pf 03758309	3.00	19
30	danusertib	2.94	18
31	r 406	2.83	16
32	cediranib	2.83	16
33	milciclib	2.77	15
34	masitinib	2.77	15
35	pha 665752	2.71	14
36	plx 4720	2.71	14
37	kw 2449	2.64	13
38	tivozanib	2.64	13
39	ast 487	2.56	12
40	atuveciclib	2.56	12
41	raf 265	2.48	11
42	motesanib	2.48	11
43	brivanib	2.48	11
44	mk 5108	2.48	11
45	azd 7762	2.30	9
46	aee 788	2.30	9
47	rebastinib	2.20	8
48	golvatinib	2.20	8
49	decernotinib	2.20	8
50	glesatinib	2.08	7

Showing top 50 of 57 compounds. Use the BiohacksAI search to explore all ABL2 modulators.

About ABL2 as a Drug Target

ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 57 compounds with documented ABL2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ABL2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.