What compounds target ACHE?

BiohacksAI has identified 68 compounds that interact with ACHE (acetylcholinesterase (Yt blood group)). Top compounds include: Physostigmine, Physostigmine, bis(12)-hupyridone [Supplementary Concept], Methylene Blue, Ranitidine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ACHE (acetylcholinesterase (Yt blood)?

ACHE is acetylcholinesterase (Yt blood group). It is a molecular target for 68 compounds documented in PubMed bioassay data. UniProt ID: P22303. NCBI Gene ID: 43.

ACHE

MOLECULAR TARGET

acetylcholinesterase (Yt blood group)

UniProt: P22303 NCBI Gene: 4368 compounds

ACHE (acetylcholinesterase (Yt blood group)) is targeted by 68 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ACHE

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Physostigmine	4.32	74
2	Physostigmine	4.32	74
3	bis(12)-hupyridone [Supplementary Concept]	2.71	14
4	Methylene Blue	2.20	8
5	Ranitidine	1.95	6
6	Chlorhexidine	1.79	5
7	Ethidium	1.79	5
8	Metergoline	1.79	5
9	Nicergoline	1.79	5
10	Berberine	1.61	4
11	Progesterone	1.61	4
12	ethopropazine	1.61	4
13	Hexachlorophene	1.61	4
14	Phenylglyoxal	1.61	4
15	Procainamide	1.61	4
16	Tilorone	1.61	4
17	Acetaldehyde	1.39	3
18	Carbaryl	1.39	3
19	Cetylpyridinium Cationic bactericidal surfactant used as	1.39	3
20	Dihydroergotamine	1.39	3
21	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.39	3
22	Methysergide	1.39	3
23	Promethazine	1.39	3
24	Thioridazine	1.39	3
25	Apigenin 5,7,4'-trihydroxy-flavone,	1.10	2
26	Caffeine	1.10	2
27	Amisulpride	1.10	2
28	Astemizole Antihistamine drug now withdrawn from	1.10	2
29	Hyoscyamine	1.10	2
30	Dinitrochlorobenzene	1.10	2
31	Disulfiram	1.10	2
32	Edaravone	1.10	2
33	Methoxsalen	1.10	2
34	pirenperone	1.10	2
35	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	1.10	2
36	Vecuronium Bromide Monoquaternary homolog of PANCURONIUM.	1.10	2
37	caffeic acid	0.69	1
38	fisetin	0.69	1
39	Fluoxetine	0.69	1
40	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
41	Quercetin	0.69	1
42	Rutin	0.69	1
43	Aripiprazole	0.69	1
44	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	0.69	1
45	Benzyl Alcohol	0.69	1
46	Bromocriptine	0.69	1
47	Cabergoline	0.69	1
48	Cilostazol	0.69	1
49	Dequalinium	0.69	1
50	dofetilide	0.69	1

Showing top 50 of 68 compounds. Use the BiohacksAI search to explore all ACHE modulators.

About ACHE as a Drug Target

ACHE (acetylcholinesterase (Yt blood group)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 68 compounds with documented ACHE interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ACHE inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.