What compounds target ADRA2A?

BiohacksAI has identified 84 compounds that interact with ADRA2A (adrenoceptor alpha 2A). Top compounds include: Yohimbine, Clonidine, Oxymetazoline, Norepinephrine Precursor of epinephrine that is secreted by, Phentolamine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ADRA2A (adrenoceptor alpha 2A)?

ADRA2A is adrenoceptor alpha 2A. It is a molecular target for 84 compounds documented in PubMed bioassay data. UniProt ID: P08913. NCBI Gene ID: 150.

ADRA2A

MOLECULAR TARGET

adrenoceptor alpha 2A

UniProt: P08913 NCBI Gene: 15084 compounds

ADRA2A (adrenoceptor alpha 2A) is targeted by 84 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ADRA2A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Yohimbine	4.54	93
2	Clonidine	3.81	44
3	Oxymetazoline	3.66	38
4	Norepinephrine Precursor of epinephrine that is secreted by	3.56	34
5	Phentolamine	3.53	33
6	Idazoxan	3.50	32
7	Epinephrine	2.83	16
8	Phenylephrine	2.77	15
9	Mianserin	2.64	13
10	Dexmedetomidine	2.64	13
11	Rilmenidine Oxazole derivative that acts as	2.30	9
12	Naphazoline	2.08	7
13	Piperoxan	2.08	7
14	Aripiprazole	1.79	5
15	Bromocriptine	1.79	5
16	Cabergoline	1.79	5
17	Dihydroergotamine	1.79	5
18	Guanfacine	1.79	5
19	Pergolide	1.79	5
20	Tolazoline	1.79	5
21	Carvedilol	1.61	4
22	Tamsulosin	1.61	4
23	Fluoxetine	1.39	3
24	Quetiapine Fumarate	1.39	3
25	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.39	3
26	Lisuride	1.39	3
27	Antazoline	1.10	2
28	Dihydroergotamine	1.10	2
29	Emetine	1.10	2
30	Guanabenz	1.10	2
31	Loxapine	1.10	2
32	Metergoline	1.10	2
33	Metoclopramide	1.10	2
34	Morphine	1.10	2
35	Phenoxybenzamine	1.10	2
36	Piribedil	1.10	2
37	Pramipexole	1.10	2
38	Promethazine	1.10	2
39	Trazodone	1.10	2
40	Amlodipine	0.69	1
41	Phenformin	0.69	1
42	Rutin	0.69	1
43	Amisulpride	0.69	1
44	Amoxapine	0.69	1
45	Astemizole Antihistamine drug now withdrawn from	0.69	1
46	Benzydamine	0.69	1
47	Buspirone	0.69	1
48	Chenodeoxycholic Acid	0.69	1
49	Chlorhexidine	0.69	1
50	Cinnarizine	0.69	1

Showing top 50 of 84 compounds. Use the BiohacksAI search to explore all ADRA2A modulators.

About ADRA2A as a Drug Target

ADRA2A (adrenoceptor alpha 2A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 84 compounds with documented ADRA2A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ADRA2A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.