What compounds target ADRA2C?

BiohacksAI has identified 76 compounds that interact with ADRA2C (adrenoceptor alpha 2C). Top compounds include: Yohimbine, Oxymetazoline, Clonidine, Idazoxan, Phentolamine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ADRA2C (adrenoceptor alpha 2C)?

ADRA2C is adrenoceptor alpha 2C. It is a molecular target for 76 compounds documented in PubMed bioassay data. UniProt ID: P18825. NCBI Gene ID: 152.

ADRA2C

MOLECULAR TARGET

adrenoceptor alpha 2C

UniProt: P18825 NCBI Gene: 15276 compounds

ADRA2C (adrenoceptor alpha 2C) is targeted by 76 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ADRA2C

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Yohimbine	4.34	76
2	Oxymetazoline	3.58	35
3	Clonidine	3.53	33
4	Idazoxan	3.50	32
5	Phentolamine	3.37	28
6	Norepinephrine Precursor of epinephrine that is secreted by	3.22	24
7	Epinephrine	2.56	12
8	Mianserin	2.48	11
9	Phenylephrine	2.20	8
10	Piperoxan	2.08	7
11	Dexmedetomidine	1.95	6
12	Naphazoline	1.95	6
13	Rilmenidine Oxazole derivative that acts as	1.79	5
14	Tolazoline	1.79	5
15	Quetiapine Fumarate	1.61	4
16	Pergolide	1.61	4
17	Aripiprazole	1.39	3
18	Bromocriptine	1.39	3
19	Carvedilol	1.39	3
20	Dihydroergotamine	1.39	3
21	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	1.39	3
22	Fluoxetine	1.10	2
23	Amisulpride	1.10	2
24	Buspirone	1.10	2
25	Cabergoline	1.10	2
26	Dihydroergotamine	1.10	2
27	Guanfacine	1.10	2
28	Lisuride	1.10	2
29	Metoclopramide	1.10	2
30	Phenoxybenzamine	1.10	2
31	Piribedil	1.10	2
32	Tamsulosin	1.10	2
33	Amlodipine	0.69	1
34	cbd	0.69	1
35	Duloxetine Hydrochloride	0.69	1
36	Rutin	0.69	1
37	Sertraline	0.69	1
38	vinpocetine	0.69	1
39	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
40	Amoxapine	0.69	1
41	Aprindine	0.69	1
42	Astemizole Antihistamine drug now withdrawn from	0.69	1
43	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	0.69	1
44	cannabidiol	0.69	1
45	Chlorhexidine	0.69	1
46	cinacalcet	0.69	1
47	Crizotinib	0.69	1
48	Dihydroergocornine	0.69	1
49	Domperidone	0.69	1
50	Emetine	0.69	1

Showing top 50 of 76 compounds. Use the BiohacksAI search to explore all ADRA2C modulators.

About ADRA2C as a Drug Target

ADRA2C (adrenoceptor alpha 2C) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 76 compounds with documented ADRA2C interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ADRA2C inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.