AKT3
MOLECULAR TARGETAKT serine/threonine kinase 3
AKT3 (AKT serine/threonine kinase 3) is targeted by 17 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting AKT3
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | midostaurin | 3.85 | 46 |
| 2 | lestaurtinib | 3.04 | 20 |
| 3 | pf 03758309 | 3.00 | 19 |
| 4 | ruboxistaurin | 2.94 | 18 |
| 5 | mk 2206 | 2.83 | 16 |
| 6 | capivasertib | 2.77 | 15 |
| 7 | gsk 690693 | 2.64 | 13 |
| 8 | gsk 1070916 | 2.20 | 8 |
| 9 | ipatasertib | 2.20 | 8 |
| 10 | a 443654 | 2.20 | 8 |
| 11 | enzastaurin | 2.08 | 7 |
| 12 | gsk 269962a | 2.08 | 7 |
| 13 | uprosertib | 1.95 | 6 |
| 14 | borussertib | 1.95 | 6 |
| 15 | afuresertib | 1.79 | 5 |
| 16 | gw770249x | 1.79 | 5 |
| 17 | hydroxyfasudil [Supplementary Concept] | 1.10 | 2 |
About AKT3 as a Drug Target
AKT3 (AKT serine/threonine kinase 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 17 compounds with documented AKT3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
AKT3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.