What compounds target ALPHA-1A?

BiohacksAI has identified 34 compounds that interact with ALPHA-1A (Alpha-1A adrenergic receptor (Norway rat)). Top compounds include: Yohimbine, Bromocriptine, Clonidine, Guanfacine, Lisuride. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ALPHA-1A (Alpha-1A adrenergic receptor)?

ALPHA-1A is Alpha-1A adrenergic receptor (Norway rat). It is a molecular target for 34 compounds documented in PubMed bioassay data. UniProt ID: P43140.

ALPHA-1A

MOLECULAR TARGET

Alpha-1A adrenergic receptor (Norway rat)

UniProt: P4314034 compounds

ALPHA-1A (Alpha-1A adrenergic receptor (Norway rat)) is targeted by 34 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ALPHA-1A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Yohimbine	1.61	4
2	Bromocriptine	1.39	3
3	Clonidine	1.39	3
4	Guanfacine	1.39	3
5	Lisuride	1.39	3
6	Pergolide	1.39	3
7	Phentolamine	1.39	3
8	Mianserin	1.10	2
9	Quetiapine Fumarate	1.10	2
10	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.10	2
11	Amoxapine	1.10	2
12	Astemizole Antihistamine drug now withdrawn from	1.10	2
13	Buspirone	1.10	2
14	Carvedilol	1.10	2
15	Cinnarizine	1.10	2
16	Cyproheptadine	1.10	2
17	Dexmedetomidine	1.10	2
18	Dihydroergotamine	1.10	2
19	Domperidone	1.10	2
20	Emetine	1.10	2
21	Epinephrine	1.10	2
22	Ergotamine	1.10	2
23	Fentanyl	1.10	2
24	Flunarizine Flunarizine is	1.10	2
25	Guanabenz	1.10	2
26	Labetalol	1.10	2
27	Maprotiline	1.10	2
28	Metergoline	1.10	2
29	Nortriptyline	1.10	2
30	Oxymetazoline	1.10	2
31	pentamidine	1.10	2
32	Promethazine	1.10	2
33	Trazodone	1.10	2
34	Econazole	0.69	1

About ALPHA-1A as a Drug Target

ALPHA-1A (Alpha-1A adrenergic receptor (Norway rat)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 34 compounds with documented ALPHA-1A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ALPHA-1A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.