What compounds target ALPHA-2A?

BiohacksAI has identified 48 compounds that interact with ALPHA-2A (Alpha-2A adrenergic receptor (human)). Top compounds include: Yohimbine, Clonidine, Dexmedetomidine, Bromocriptine, Guanfacine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ALPHA-2A (Alpha-2A adrenergic receptor)?

ALPHA-2A is Alpha-2A adrenergic receptor (human). It is a molecular target for 48 compounds documented in PubMed bioassay data. UniProt ID: P08913.

ALPHA-2A

MOLECULAR TARGET

Alpha-2A adrenergic receptor (human)

UniProt: P0891348 compounds

ALPHA-2A (Alpha-2A adrenergic receptor (human)) is targeted by 48 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ALPHA-2A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Yohimbine	2.64	13
2	Clonidine	2.08	7
3	Dexmedetomidine	1.61	4
4	Bromocriptine	1.39	3
5	Guanfacine	1.39	3
6	Lisuride	1.39	3
7	Pergolide	1.39	3
8	Mianserin	1.10	2
9	Quetiapine Fumarate	1.10	2
10	Sertraline	1.10	2
11	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.10	2
12	Amoxapine	1.10	2
13	Astemizole Antihistamine drug now withdrawn from	1.10	2
14	Carvedilol	1.10	2
15	Cinnarizine	1.10	2
16	Cyclizine	1.10	2
17	Cyproheptadine	1.10	2
18	Dihydroergotamine	1.10	2
19	Dimenhydrinate	1.10	2
20	Disulfiram	1.10	2
21	Domperidone	1.10	2
22	Econazole	1.10	2
23	Emetine	1.10	2
24	Epinephrine	1.10	2
25	Ergonovine	1.10	2
26	Ergotamine	1.10	2
27	Flunarizine Flunarizine is	1.10	2
28	Guanabenz	1.10	2
29	Hexachlorophene	1.10	2
30	Maprotiline	1.10	2
31	Metergoline	1.10	2
32	Methylergonovine	1.10	2
33	Methysergide	1.10	2
34	Metoclopramide	1.10	2
35	Miconazole	1.10	2
36	Nortriptyline	1.10	2
37	Oxymetazoline	1.10	2
38	pentamidine	1.10	2
39	Phentolamine	1.10	2
40	Promethazine	1.10	2
41	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	1.10	2
42	Sulpiride	1.10	2
43	Trazodone	1.10	2
44	2-Acetylaminofluorene	0.69	1
45	Clotrimazole	0.69	1
46	Danazol	0.69	1
47	Morphine	0.69	1
48	Norepinephrine Precursor of epinephrine that is secreted by	0.69	1

About ALPHA-2A as a Drug Target

ALPHA-2A (Alpha-2A adrenergic receptor (human)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 48 compounds with documented ALPHA-2A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ALPHA-2A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.