What compounds target AURKA?

BiohacksAI has identified 72 compounds that interact with AURKA (aurora kinase A). Top compounds include: erlotinib, cabozantinib, foretinib, tozasertib, midostaurin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is AURKA (aurora kinase A)?

AURKA is aurora kinase A. It is a molecular target for 72 compounds documented in PubMed bioassay data. UniProt ID: O14965. NCBI Gene ID: 6790.

AURKA

MOLECULAR TARGET

aurora kinase A

UniProt: O14965 NCBI Gene: 679072 compounds

AURKA (aurora kinase A) is targeted by 72 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting AURKA

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	cabozantinib	4.39	80
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	midostaurin	3.85	46
6	inamrinone	3.83	45
7	brigatinib	3.81	44
8	pazopanib	3.69	39
9	6bio	3.50	32
10	bms 387032	3.47	31
11	tae 684	3.43	30
12	fedratinib	3.40	29
13	gilteritinib	3.40	29
14	linifanib	3.33	27
15	mln 8054	3.33	27
16	fexagratinib	3.33	27
17	alisertib	3.30	26
18	sp 600125	3.22	24
19	indirubin 3 monoxime	3.22	24
20	entrectinib	3.18	23
21	sulfuretin	3.14	22
22	jnj 7706621	3.09	21
23	at 9283	3.09	21
24	upadacitinib	3.09	21
25	lestaurtinib	3.04	20
26	pf 03758309	3.00	19
27	danusertib	2.94	18
28	defosbarasertib	2.89	17
29	orantinib	2.89	17
30	barasertib	2.89	17
31	go 6976	2.89	17
32	r 406	2.83	16
33	k 252a	2.83	16
34	milciclib	2.77	15
35	pf 00562271	2.77	15
36	hesperadin	2.77	15
37	plx 4720	2.71	14
38	enmd 2076	2.71	14
39	naphthazalin	2.71	14
40	kw 2449	2.64	13
41	bemcentinib	2.64	13
42	defactinib	2.48	11
43	mk 5108	2.48	11
44	bms 754807	2.30	9
45	azd 1480	2.30	9
46	reversine	2.30	9
47	pha 680632	2.30	9
48	gsk 1070916	2.20	8
49	gandotinib	2.20	8
50	gsk 650394	2.20	8

Showing top 50 of 72 compounds. Use the BiohacksAI search to explore all AURKA modulators.

About AURKA as a Drug Target

AURKA (aurora kinase A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 72 compounds with documented AURKA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

AURKA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.