What compounds target AXL?

BiohacksAI has identified 47 compounds that interact with AXL (AXL receptor tyrosine kinase). Top compounds include: gefitinib, erlotinib, alvocidib, cabozantinib, foretinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is AXL (AXL receptor tyrosine)?

AXL is AXL receptor tyrosine kinase. It is a molecular target for 47 compounds documented in PubMed bioassay data. UniProt ID: P30530. NCBI Gene ID: 558.

AXL

MOLECULAR TARGET

AXL receptor tyrosine kinase

UniProt: P30530 NCBI Gene: 55847 compounds

AXL (AXL receptor tyrosine kinase) is targeted by 47 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting AXL

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	alvocidib	4.52	91
4	cabozantinib	4.39	80
5	foretinib	4.34	76
6	tozasertib	4.33	75
7	vandetanib	4.30	73
8	bosutinib	4.08	58
9	quizartinib	3.99	53
10	midostaurin	3.85	46
11	neratinib	3.66	38
12	nintedanib	3.61	36
13	canertinib	3.53	33
14	pelitinib	3.50	32
15	tae 684	3.43	30
16	fedratinib	3.40	29
17	gilteritinib	3.40	29
18	bms 777607	3.37	28
19	linifanib	3.33	27
20	mln 8054	3.33	27
21	tandutinib	3.22	24
22	dovitinib	3.09	21
23	jnj 7706621	3.09	21
24	lestaurtinib	3.04	20
25	defosbarasertib	2.89	17
26	r 406	2.83	16
27	cediranib	2.83	16
28	sotrastaurin	2.77	15
29	pha 665752	2.71	14
30	kw 2449	2.64	13
31	bemcentinib	2.64	13
32	ast 487	2.56	12
33	merestinib	2.48	11
34	bms 754807	2.30	9
35	su 014813	2.20	8
36	rebastinib	2.20	8
37	enzastaurin	2.08	7
38	sns 314 mesylate	1.95	6
39	itacitinib	1.95	6
40	Crizotinib	1.79	5
41	aigialomycin d	1.79	5
42	exelixis	1.79	5
43	Sorafenib	1.61	4
44	Quercetin	0.69	1
45	Afatinib	0.69	1
46	Axitinib	0.69	1
47	Dasatinib	0.69	1

About AXL as a Drug Target

AXL (AXL receptor tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 47 compounds with documented AXL interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

AXL inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.