What compounds target BRCA1?

BiohacksAI has identified 34 compounds that interact with BRCA1 (BRCA1 DNA repair associated). Top compounds include: Apigenin 5,7,4'-trihydroxy-flavone,, Resveratrol, Methotrexate, Astemizole Antihistamine drug now withdrawn from, Azacitidine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is BRCA1 (BRCA1 DNA repair)?

BRCA1 is BRCA1 DNA repair associated. It is a molecular target for 34 compounds documented in PubMed bioassay data. UniProt ID: P38398. NCBI Gene ID: 672.

BRCA1

MOLECULAR TARGET

BRCA1 DNA repair associated

UniProt: P38398 NCBI Gene: 67234 compounds

BRCA1 (BRCA1 DNA repair associated) is targeted by 34 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting BRCA1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
2	Resveratrol	0.69	1
3	Methotrexate	0.69	1
4	Astemizole Antihistamine drug now withdrawn from	0.69	1
5	Azacitidine	0.69	1
6	Azacitidine	0.69	1
7	Calcimycin	0.69	1
8	calycosin	0.69	1
9	Chlorhexidine	0.69	1
10	Ciclopirox	0.69	1
11	Colchicine	0.69	1
12	colchine	0.69	1
13	cycloheximide	0.69	1
14	Cytarabine	0.69	1
15	Demecolcine	0.69	1
16	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
17	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
18	dihydrorotenone	0.69	1
19	Fluspirilene	0.69	1
20	gedunin	0.69	1
21	Hexachlorophene	0.69	1
22	lidoflazine	0.69	1
23	Melphalan	0.69	1
24	Niclosamide	0.69	1
25	Nocodazole Nocodazole is	0.69	1
26	paxilline	0.69	1
27	Podophyllotoxin	0.69	1
28	rafoxanide	0.69	1
29	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	0.69	1
30	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	0.69	1
31	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	0.69	1
32	Trifluridine	0.69	1
33	Tubercidin	0.69	1
34	vinblastine sulfate	0.69	1

About BRCA1 as a Drug Target

BRCA1 (BRCA1 DNA repair associated) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 34 compounds with documented BRCA1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

BRCA1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.