What compounds target BRD4?

BiohacksAI has identified 32 compounds that interact with BRD4 (bromodomain containing 4). Top compounds include: ly 294002, panobinostat, bi 2536, romidepsin, belinostat. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is BRD4 (bromodomain containing 4)?

BRD4 is bromodomain containing 4. It is a molecular target for 32 compounds documented in PubMed bioassay data. UniProt ID: O60885. NCBI Gene ID: 23476.

BRD4

MOLECULAR TARGET

bromodomain containing 4

UniProt: O60885 NCBI Gene: 2347632 compounds

BRD4 (bromodomain containing 4) is targeted by 32 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting BRD4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	ly 294002	4.84	126
2	panobinostat	4.26	70
3	bi 2536	4.01	54
4	romidepsin	3.95	51
5	belinostat	3.91	49
6	lenalidomide	3.91	49
7	alprazolam	3.89	48
8	dinaciclib	3.87	47
9	molibresib	3.81	44
10	apabetalone	3.66	38
11	sb 202190	3.64	37
12	birabresib	3.47	31
13	fedratinib	3.40	29
14	tacedinaline	3.37	28
15	cloxyquin	3.04	20
16	mivebresib	3.00	19
17	nitroxoline	3.00	19
18	volasertib	2.94	18
19	abbv 744	2.56	12
20	gsk046	2.40	10
21	gsk620	2.30	9
22	azd 5153	2.20	8
23	inobrodib	2.20	8
24	ischemin	2.20	8
25	methylpyrrolidone	2.20	8
26	gsk778	2.08	7
27	withanolide e	1.95	6
28	35 dimethyl 4 phenylisoxazole	1.79	5
29	ly294002	0.69	1
30	bdb chembl4864701	0.69	1
31	bdb chembl4878894	0.69	1
32	bdb chembl5083025	0.69	1

About BRD4 as a Drug Target

BRD4 (bromodomain containing 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 32 compounds with documented BRD4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

BRD4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.