What compounds target CA1?

BiohacksAI has identified 48 compounds that interact with CA1 (carbonic anhydrase 1). Top compounds include: Zonisamide, benzolamide, Sulpiride, Histamine, Histidine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CA1 (carbonic anhydrase 1)?

CA1 is carbonic anhydrase 1. It is a molecular target for 48 compounds documented in PubMed bioassay data. UniProt ID: P00915. NCBI Gene ID: 759.

CA1

MOLECULAR TARGET

carbonic anhydrase 1

UniProt: P00915 NCBI Gene: 75948 compounds

CA1 (carbonic anhydrase 1) is targeted by 48 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CA1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Zonisamide	4.04	56
2	benzolamide	3.64	37
3	Sulpiride	3.37	28
4	Histamine	3.09	21
5	Histidine	2.89	17
6	Tyrosine	2.48	11
7	Tyrosine	2.48	11
8	Levodopa	2.48	11
9	Sodium Azide	2.20	8
10	Hydrogen Cyanide Hydrogen cyanide (HCN);	2.08	7
11	Hydrogen Sulfide	2.08	7
12	Hydrogen Sulfide	2.08	7
13	Sulfides Chemical groups containing	2.08	7
14	Chlorthalidone	1.95	6
15	Epinephrine	1.61	4
16	Furosemide	1.61	4
17	Salicylic Acid	1.61	4
18	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	1.39	3
19	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	1.39	3
20	Indapamide	1.39	3
21	Sulfanilamide	1.39	3
22	Carnosine	1.10	2
23	chrysin	1.10	2
24	Quercetin	1.10	2
25	Bortezomib	1.10	2
26	Bumetanide	1.10	2
27	Cyanides Inorganic salts of HYDROGEN CYANIDE containing	1.10	2
28	stx64	1.10	2
29	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
30	caffeic acid	0.69	1
31	Catechin	0.69	1
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
33	Resveratrol	0.69	1
34	Spermidine	0.69	1
35	Aspartic Acid	0.69	1
36	d609	0.69	1
37	Catechin	0.69	1
38	Famotidine	0.69	1
39	Vanillic Acid	0.69	1
40	Glutamic Acid	0.69	1
41	Glutamic Acid	0.69	1
42	Lacosamide	0.69	1
43	ninhydrin	0.69	1
44	Phenol	0.69	1
45	4-Hydroxybenzoate-3-Monooxygenase	0.69	1
46	prunetin	0.69	1
47	Sildenafil Citrate	0.69	1
48	thiamine	0.69	1

About CA1 as a Drug Target

CA1 (carbonic anhydrase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 48 compounds with documented CA1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CA1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.