What compounds target CA2?

BiohacksAI has identified 44 compounds that interact with CA2 (carbonic anhydrase 2). Top compounds include: Sulfanilamide, Zonisamide, Mafenide, Celecoxib, benzolamide. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CA2 (carbonic anhydrase 2)?

CA2 is carbonic anhydrase 2. It is a molecular target for 44 compounds documented in PubMed bioassay data. UniProt ID: P00918. NCBI Gene ID: 760.

CA2

MOLECULAR TARGET

carbonic anhydrase 2

UniProt: P00918 NCBI Gene: 76044 compounds

CA2 (carbonic anhydrase 2) is targeted by 44 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CA2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Sulfanilamide	4.44	84
2	Zonisamide	4.28	71
3	Mafenide	4.04	56
4	Celecoxib	3.93	50
5	benzolamide	3.81	44
6	Sulpiride	3.78	43
7	Phenol	2.71	14
8	Tyrosine	2.64	13
9	Tyrosine	2.64	13
10	Indapamide	2.40	10
11	stx64	1.95	6
12	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	1.61	4
13	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	1.61	4
14	Chlorthalidone	1.61	4
15	Salicylic Acid	1.61	4
16	Furosemide	1.39	3
17	Probenecid	1.39	3
18	chrysin	1.10	2
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.10	2
20	Quercetin	1.10	2
21	Bortezomib	1.10	2
22	Bumetanide	1.10	2
23	Vanillic Acid	1.10	2
24	Metolazone	1.10	2
25	tyrosol	1.10	2
26	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
27	caffeic acid	0.69	1
28	Catechin	0.69	1
29	Histidine	0.69	1
30	Kaempferols	0.69	1
31	Resveratrol	0.69	1
32	Spermidine	0.69	1
33	d609	0.69	1
34	Catechin	0.69	1
35	Famotidine	0.69	1
36	Hydrogen Sulfide	0.69	1
37	Hydrogen Sulfide	0.69	1
38	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	0.69	1
39	Lacosamide	0.69	1
40	4-Hydroxybenzoate-3-Monooxygenase	0.69	1
41	Sulfadiazine	0.69	1
42	Sulfides Chemical groups containing	0.69	1
43	thiamine	0.69	1
44	Tryptophan	0.69	1

About CA2 as a Drug Target

CA2 (carbonic anhydrase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 44 compounds with documented CA2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CA2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.