What compounds target CA5A?

BiohacksAI has identified 35 compounds that interact with CA5A (carbonic anhydrase 5A). Top compounds include: Zonisamide, Indapamide, Chlorthalidone, Histamine, benzolamide. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CA5A (carbonic anhydrase 5A)?

CA5A is carbonic anhydrase 5A. It is a molecular target for 35 compounds documented in PubMed bioassay data. UniProt ID: P35218. NCBI Gene ID: 763.

CA5A

MOLECULAR TARGET

carbonic anhydrase 5A

UniProt: P35218 NCBI Gene: 76335 compounds

CA5A (carbonic anhydrase 5A) is targeted by 35 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CA5A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Zonisamide	2.40	10
2	Indapamide	1.95	6
3	Chlorthalidone	1.61	4
4	Histamine	1.61	4
5	benzolamide	1.39	3
6	Furosemide	1.39	3
7	Histidine	1.10	2
8	Bumetanide	1.10	2
9	Celecoxib	1.10	2
10	Vanillic Acid	1.10	2
11	Metolazone	1.10	2
12	stx64	1.10	2
13	Tryptophan	1.10	2
14	caffeic acid	0.69	1
15	Catechin	0.69	1
16	Folic Acid	0.69	1
17	Tyrosine	0.69	1
18	Quercetin	0.69	1
19	Resveratrol	0.69	1
20	Spermidine	0.69	1
21	Tyrosine	0.69	1
22	Bortezomib	0.69	1
23	Famotidine	0.69	1
24	Hydrochloric Acid	0.69	1
25	Hydrogen Cyanide Hydrogen cyanide (HCN);	0.69	1
26	hydrogen iodide	0.69	1
27	Hydrogen Sulfide	0.69	1
28	Hydrogen Sulfide	0.69	1
29	Lacosamide	0.69	1
30	Levodopa	0.69	1
31	Nitric Acid Nitric acid (HNO3).	0.69	1
32	Spermine	0.69	1
33	Sulfides Chemical groups containing	0.69	1
34	Sulpiride	0.69	1
35	tyrosol	0.69	1

About CA5A as a Drug Target

CA5A (carbonic anhydrase 5A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 35 compounds with documented CA5A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CA5A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.