What compounds target CASP3?

BiohacksAI has identified 41 compounds that interact with CASP3 (caspase 3). Top compounds include: Disulfiram, Astemizole Antihistamine drug now withdrawn from, Dactinomycin, Celecoxib, Lovastatin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CASP3 (caspase 3)?

CASP3 is caspase 3. It is a molecular target for 41 compounds documented in PubMed bioassay data. UniProt ID: CAC88866. NCBI Gene ID: 836.

CASP3

MOLECULAR TARGET

caspase 3

UniProt: CAC88866 NCBI Gene: 83641 compounds

CASP3 (caspase 3) is targeted by 41 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CASP3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Disulfiram	1.79	5
2	Astemizole Antihistamine drug now withdrawn from	1.61	4
3	Dactinomycin	1.61	4
4	Celecoxib	1.39	3
5	Lovastatin	1.39	3
6	Aprepitant	1.10	2
7	Bortezomib	1.10	2
8	Daunorubicin	1.10	2
9	Ethinyl Estradiol	1.10	2
10	Methylcholanthrene	1.10	2
11	o-Phthalaldehyde	1.10	2
12	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	1.10	2
13	Thioridazine	1.10	2
14	Atorvastatin	0.69	1
15	Methylene Blue	0.69	1
16	Resveratrol	0.69	1
17	amlexanox	0.69	1
18	celastrol	0.69	1
19	Cetylpyridinium Cationic bactericidal surfactant used as	0.69	1
20	Dasatinib	0.69	1
21	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	0.69	1
22	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	0.69	1
23	Leflunomide	0.69	1
24	Lithocholic Acid	0.69	1
25	Lumefantrine	0.69	1
26	Maprotiline	0.69	1
27	Melphalan	0.69	1
28	Mometasone Furoate	0.69	1
29	ninhydrin	0.69	1
30	Nocodazole Nocodazole is	0.69	1
31	oxatomide [Supplementary Concept] structure;	0.69	1
32	Oxymetholone	0.69	1
33	Perphenazine	0.69	1
34	piceatannol	0.69	1
35	Promethazine	0.69	1
36	Reserpine	0.69	1
37	Retinaldehyde	0.69	1
38	Safrole	0.69	1
39	Spermine	0.69	1
40	triflupromazine hydrochloride	0.69	1
41	tyrphostin ag 1295	0.69	1

About CASP3 as a Drug Target

CASP3 (caspase 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 41 compounds with documented CASP3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CASP3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.