What compounds target CFTR?

BiohacksAI has identified 66 compounds that interact with CFTR (CF transmembrane conductance regulator). Top compounds include: Genistein, Apigenin 5,7,4'-trihydroxy-flavone,, Anisomycin, cycloheximide, kenpaullone. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CFTR (CF transmembrane conductance)?

CFTR is CF transmembrane conductance regulator. It is a molecular target for 66 compounds documented in PubMed bioassay data. UniProt ID: P13569. NCBI Gene ID: 1080.

CFTR

MOLECULAR TARGET

CF transmembrane conductance regulator

UniProt: P13569 NCBI Gene: 108066 compounds

CFTR (CF transmembrane conductance regulator) is targeted by 66 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CFTR

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Genistein	1.95	6
2	Apigenin 5,7,4'-trihydroxy-flavone,	1.39	3
3	Anisomycin	1.39	3
4	cycloheximide	1.39	3
5	kenpaullone	1.39	3
6	Vorinostat	1.39	3
7	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.39	3
8	Hydrocortisone	1.10	2
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.10	2
10	Betamethasone	1.10	2
11	Bumetanide	1.10	2
12	Chlorthalidone	1.10	2
13	Ethidium	1.10	2
14	Hydrocortisone	1.10	2
15	Cervugid [Supplementary Concept]	1.10	2
16	Medroxyprogesterone Acetate	1.10	2
17	Vitamin K 3	1.10	2
18	Mestranol	1.10	2
19	Nisoldipine	1.10	2
20	Quinestrol	1.10	2
21	Budesonide	0.69	1
22	Methylene Blue	0.69	1
23	Prednisolone	0.69	1
24	6-Aminonicotinamide	0.69	1
25	alsterpaullone	0.69	1
26	Hyoscyamine	0.69	1
27	Beclomethasone	0.69	1
28	Carbazilquinone	0.69	1
29	Carbidopa	0.69	1
30	cardamonin	0.69	1
31	Desoximetasone	0.69	1
32	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
33	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
34	Digoxin	0.69	1
35	Dinitrochlorobenzene	0.69	1
36	Disulfiram	0.69	1
37	Flumethasone	0.69	1
38	Fluocinolone Acetonide	0.69	1
39	Fluorometholone	0.69	1
40	Flurandrenolone	0.69	1
41	gamma-Linolenic Acid	0.69	1
42	Glyburide	0.69	1
43	Halcinonide	0.69	1
44	Hexachlorophene	0.69	1
45	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	0.69	1
46	Medroxyprogesterone	0.69	1
47	Melengestrol Acetate	0.69	1
48	Methylprednisolone	0.69	1
49	Methylprednisolone Acetate Methylprednisolone derivative that is used as	0.69	1
50	mg624	0.69	1

Showing top 50 of 66 compounds. Use the BiohacksAI search to explore all CFTR modulators.

About CFTR as a Drug Target

CFTR (CF transmembrane conductance regulator) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 66 compounds with documented CFTR interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CFTR inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.