What compounds target CHAIN?

BiohacksAI has identified 197 compounds that interact with CHAIN (Chain B, HADH2 protein (human)). Top compounds include: myricetin-3-O-galactopyranoside [Supplementary Concept], Aurintricarboxylic Acid, Adenosine Triphosphate, Quercetin, Luteolin 5,7,3',4'-tetrahydroxy-flavone,. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CHAIN (Chain B, HADH2)?

CHAIN is Chain B, HADH2 protein (human). It is a molecular target for 197 compounds documented in PubMed bioassay data. UniProt ID: 2O23_A.

CHAIN

MOLECULAR TARGET

Chain B, HADH2 protein (human)

UniProt: 2O23_A197 compounds

CHAIN (Chain B, HADH2 protein (human)) is targeted by 197 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CHAIN

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	3.30	26
2	Aurintricarboxylic Acid	3.09	21
3	Adenosine Triphosphate	2.94	18
4	Quercetin	2.83	16
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	2.71	14
6	Thyroxine	2.71	14
7	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	2.48	11
8	Methyldopa	2.48	11
9	Guanosine Diphosphate	2.40	10
10	Oleic Acid	2.30	9
11	Daunorubicin	2.30	9
12	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	2.30	9
13	Thioctic Acid	2.30	9
14	Camptothecin	2.20	8
15	Ethoxyquin Antioxidant; also	2.20	8
16	Harmaline	2.20	8
17	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	2.20	8
18	Idarubicin	2.20	8
19	Levodopa	2.20	8
20	Disulfiram	2.08	7
21	juglone hydroxylase [Supplementary Concept] catalyzes	2.08	7
22	Masoprocol	2.08	7
23	Norepinephrine Precursor of epinephrine that is secreted by	2.08	7
24	Nitroprusside	2.08	7
25	Methylene Blue	1.95	6
26	Resveratrol	1.95	6
27	Carmine Coloring matter from	1.95	6
28	Epinephrine	1.95	6
29	Ethidium	1.95	6
30	ag490	1.79	5
31	Bumetanide	1.79	5
32	Dihydroxyphenylalanine	1.79	5
33	Ornithine	1.61	4
34	Progesterone	1.61	4
35	Sirolimus	1.61	4
36	alpha-Linolenic Acid	1.61	4
37	Aminocaproic Acid	1.61	4
38	Ampicillin Semi-synthetic derivative of penicillin that functions as	1.61	4
39	Anisomycin	1.61	4
40	Carbaryl	1.61	4
41	Carbidopa	1.61	4
42	Dactinomycin	1.61	4
43	Dequalinium	1.61	4
44	Echinacea	1.61	4
45	Folic Acid	1.61	4
46	Hydrocortisone	1.61	4
47	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.61	4
48	Pseudoephedrine	1.61	4
49	Putrescine	1.61	4
50	Labetalol	1.61	4

Showing top 50 of 197 compounds. Use the BiohacksAI search to explore all CHAIN modulators.

About CHAIN as a Drug Target

CHAIN (Chain B, HADH2 protein (human)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 197 compounds with documented CHAIN interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CHAIN inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.