What compounds target CHRM2?

BiohacksAI has identified 57 compounds that interact with CHRM2 (cholinergic receptor muscarinic 2). Top compounds include: Hyoscyamine, Arecoline, N-Methylscopolamine, Pilocarpine, Scopolamine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CHRM2 (cholinergic receptor muscarinic)?

CHRM2 is cholinergic receptor muscarinic 2. It is a molecular target for 57 compounds documented in PubMed bioassay data. UniProt ID: P08172. NCBI Gene ID: 1129.

CHRM2

MOLECULAR TARGET

cholinergic receptor muscarinic 2

UniProt: P08172 NCBI Gene: 112957 compounds

CHRM2 (cholinergic receptor muscarinic 2) is targeted by 57 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CHRM2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Hyoscyamine	4.52	91
2	Arecoline	3.95	51
3	N-Methylscopolamine	3.43	30
4	Pilocarpine	3.09	21
5	Scopolamine	2.94	18
6	Muscarine	2.71	14
7	Hyoscyamine	2.30	9
8	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.95	6
9	Quetiapine Fumarate	1.79	5
10	hexahydrosiladiphenidol	1.79	5
11	Ipratropium	1.61	4
12	Mianserin	1.39	3
13	Loxapine	1.39	3
14	Promethazine	1.39	3
15	Strychnine	1.39	3
16	Tolterodine Tartrate	1.39	3
17	Cyproheptadine	1.10	2
18	Dimethindene	1.10	2
19	ethopropazine	1.10	2
20	Nortriptyline	1.10	2
21	protriptyline	1.10	2
22	cbd	0.69	1
23	Quercetin	0.69	1
24	Amoxapine	0.69	1
25	Aripiprazole	0.69	1
26	Astemizole Antihistamine drug now withdrawn from	0.69	1
27	Axitinib	0.69	1
28	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	0.69	1
29	Benzydamine	0.69	1
30	Butaclamol	0.69	1
31	candesartan cilexetil [Supplementary Concept]	0.69	1
32	cannabidiol	0.69	1
33	Chlorpheniramine	0.69	1
34	Cinnarizine	0.69	1
35	Cyclizine	0.69	1
36	Dequalinium	0.69	1
37	Desogestrel	0.69	1
38	dofetilide	0.69	1
39	Flunarizine Flunarizine is	0.69	1
40	Gabexate	0.69	1
41	Hydroxyzine	0.69	1
42	Ibogaine	0.69	1
43	Ivabradine	0.69	1
44	Levallorphan	0.69	1
45	Loratadine	0.69	1
46	Metergoline	0.69	1
47	Nicergoline	0.69	1
48	Niclosamide	0.69	1
49	Norethindrone Acetate Acetate ester of norethindrone that is used as	0.69	1
50	oxatomide [Supplementary Concept] structure;	0.69	1

Showing top 50 of 57 compounds. Use the BiohacksAI search to explore all CHRM2 modulators.

About CHRM2 as a Drug Target

CHRM2 (cholinergic receptor muscarinic 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 57 compounds with documented CHRM2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CHRM2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.