What compounds target CHRM4?

BiohacksAI has identified 44 compounds that interact with CHRM4 (cholinergic receptor muscarinic 4). Top compounds include: Hyoscyamine, Arecoline, Pilocarpine, N-Methylscopolamine, Muscarine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CHRM4 (cholinergic receptor muscarinic)?

CHRM4 is cholinergic receptor muscarinic 4. It is a molecular target for 44 compounds documented in PubMed bioassay data. UniProt ID: P08173. NCBI Gene ID: 1132.

CHRM4

MOLECULAR TARGET

cholinergic receptor muscarinic 4

UniProt: P08173 NCBI Gene: 113244 compounds

CHRM4 (cholinergic receptor muscarinic 4) is targeted by 44 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CHRM4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Hyoscyamine	3.69	39
2	Arecoline	3.61	36
3	Pilocarpine	2.77	15
4	N-Methylscopolamine	2.40	10
5	Muscarine	1.95	6
6	Scopolamine	1.79	5
7	hexahydrosiladiphenidol	1.39	3
8	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.10	2
9	Diphenhydramine	1.10	2
10	Hyoscyamine	1.10	2
11	Loxapine	1.10	2
12	Nortriptyline	1.10	2
13	Promazine	1.10	2
14	Propantheline	1.10	2
15	Strychnine	1.10	2
16	triflupromazine hydrochloride	1.10	2
17	Quetiapine Fumarate	0.69	1
18	vinpocetine	0.69	1
19	Bisphenol A-Glycidyl Methacrylate	0.69	1
20	Butaclamol	0.69	1
21	Butylscopolammonium Bromide Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of	0.69	1
22	Cefotetan	0.69	1
23	chlorprothixene hydrochloride	0.69	1
24	cinoxacin	0.69	1
25	clofilium tosylate	0.69	1
26	Cyclizine	0.69	1
27	Cyproheptadine	0.69	1
28	Desoxycorticosterone Acetate	0.69	1
29	Doxazosin	0.69	1
30	Ethylenethiourea	0.69	1
31	Maprotiline	0.69	1
32	Medroxyprogesterone	0.69	1
33	mg624	0.69	1
34	Nicardipine	0.69	1
35	Nicorandil	0.69	1
36	Perphenazine	0.69	1
37	Podophyllotoxin	0.69	1
38	Promethazine	0.69	1
39	propionylpromazine hydrochloride	0.69	1
40	Ranolazine	0.69	1
41	Thioridazine	0.69	1
42	Tilorone	0.69	1
43	Triamcinolone Acetonide	0.69	1
44	Vincamine	0.69	1

About CHRM4 as a Drug Target

CHRM4 (cholinergic receptor muscarinic 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 44 compounds with documented CHRM4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CHRM4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.