What compounds target CIT?

BiohacksAI has identified 39 compounds that interact with CIT (citron rho-interacting serine/threonine kinase). Top compounds include: gefitinib, erlotinib, sb 203580, alvocidib, foretinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CIT (citron rho-interacting serine/threonine)?

CIT is citron rho-interacting serine/threonine kinase. It is a molecular target for 39 compounds documented in PubMed bioassay data. UniProt ID: O14578. NCBI Gene ID: 11113.

CIT

MOLECULAR TARGET

citron rho-interacting serine/threonine kinase

UniProt: O14578 NCBI Gene: 1111339 compounds

CIT (citron rho-interacting serine/threonine kinase) is targeted by 39 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CIT

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	sb 203580	4.92	136
4	alvocidib	4.52	91
5	foretinib	4.34	76
6	vandetanib	4.30	73
7	ruxolitinib	4.23	68
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	bi 2536	4.01	54
11	vatalanib	3.69	39
12	abemaciclib	3.66	38
13	fasudil	3.66	38
14	sb 202190	3.64	37
15	baricitinib	3.56	34
16	canertinib	3.53	33
17	pelitinib	3.50	32
18	bms 387032	3.47	31
19	fedratinib	3.40	29
20	gilteritinib	3.40	29
21	dovitinib	3.09	21
22	lestaurtinib	3.04	20
23	ruboxistaurin	2.94	18
24	defosbarasertib	2.89	17
25	momelotinib	2.89	17
26	r 406	2.83	16
27	kw 2449	2.64	13
28	gsk 690693	2.64	13
29	ast 487	2.56	12
30	raf 265	2.48	11
31	motesanib	2.48	11
32	su 014813	2.20	8
33	gsk 1070916	2.20	8
34	y 39983	2.20	8
35	cyc 116	2.08	7
36	afuresertib	1.79	5
37	Sorafenib	1.39	3
38	Afatinib	0.69	1
39	hydroxyfasudil [Supplementary Concept]	0.69	1

About CIT as a Drug Target

CIT (citron rho-interacting serine/threonine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 39 compounds with documented CIT interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CIT inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.