What compounds target CREB1?

BiohacksAI has identified 43 compounds that interact with CREB1 (cAMP responsive element binding protein 1). Top compounds include: cycloheximide, Disulfiram, Azacitidine, Azacitidine, Apigenin 5,7,4'-trihydroxy-flavone,. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CREB1 (cAMP responsive element)?

CREB1 is cAMP responsive element binding protein 1. It is a molecular target for 43 compounds documented in PubMed bioassay data. NCBI Gene ID: 1385.

CREB1

MOLECULAR TARGET

cAMP responsive element binding protein 1

NCBI Gene: 138543 compounds

CREB1 (cAMP responsive element binding protein 1) is targeted by 43 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CREB1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	cycloheximide	2.56	12
2	Disulfiram	2.20	8
3	Azacitidine	1.95	6
4	Azacitidine	1.95	6
5	Apigenin 5,7,4'-trihydroxy-flavone,	1.61	4
6	Levalbuterol	1.61	4
7	Adenosine Monophosphate Adenine nucleotide containing	1.61	4
8	Levalbuterol	1.61	4
9	Bortezomib	1.61	4
10	Clofarabine	1.61	4
11	Dactinomycin	1.61	4
12	Danazol	1.61	4
13	Emetine	1.61	4
14	Ethidium	1.61	4
15	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	1.61	4
16	Sulbactam	1.61	4
17	trequinsin hydrochloride	1.61	4
18	chrysin	1.10	2
19	Genistein	1.10	2
20	Quercetin	1.10	2
21	Testosterone	1.10	2
22	Ciclopirox	1.10	2
23	Cladribine	1.10	2
24	Clenbuterol	1.10	2
25	Corticosterone	1.10	2
26	Dasatinib	1.10	2
27	Daunorubicin	1.10	2
28	Dinoprostone	1.10	2
29	Epinephrine	1.10	2
30	Ethinyl Estradiol	1.10	2
31	Imatinib Mesylate	1.10	2
32	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	1.10	2
33	Nisoldipine	1.10	2
34	Nocodazole Nocodazole is	1.10	2
35	Masoprocol	1.10	2
36	Norepinephrine Precursor of epinephrine that is secreted by	1.10	2
37	o-Phthalaldehyde	1.10	2
38	Oxyphenbutazone	1.10	2
39	pivampicillin	1.10	2
40	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	1.10	2
41	Salmeterol Xinafoate	1.10	2
42	Tilorone	1.10	2
43	Urea	1.10	2

About CREB1 as a Drug Target

CREB1 (cAMP responsive element binding protein 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 43 compounds with documented CREB1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CREB1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.