What compounds target CSK?

BiohacksAI has identified 36 compounds that interact with CSK (C-terminal Src kinase). Top compounds include: erlotinib, ibrutinib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CSK (C-terminal Src kinase)?

CSK is C-terminal Src kinase. It is a molecular target for 36 compounds documented in PubMed bioassay data. UniProt ID: P41240. NCBI Gene ID: 1445.

CSK

MOLECULAR TARGET

C-terminal Src kinase

UniProt: P41240 NCBI Gene: 144536 compounds

CSK (C-terminal Src kinase) is targeted by 36 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CSK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	ibrutinib	4.86	128
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	ponatinib	4.26	70
7	nilotinib	4.17	64
8	bosutinib	4.08	58
9	midostaurin	3.85	46
10	brigatinib	3.81	44
11	neratinib	3.66	38
12	canertinib	3.53	33
13	pelitinib	3.50	32
14	tae 684	3.43	30
15	fedratinib	3.40	29
16	mln 8054	3.33	27
17	saracatinib	3.33	27
18	dabrafenib	3.30	26
19	at 9283	3.09	21
20	lestaurtinib	3.04	20
21	defosbarasertib	2.89	17
22	r 406	2.83	16
23	pd 173074	2.83	16
24	plx 4720	2.71	14
25	kw 2449	2.64	13
26	ast 487	2.56	12
27	tak 285	2.40	10
28	azd 7762	2.30	9
29	bms 754807	2.30	9
30	azd 6482	2.30	9
31	rebastinib	2.20	8
32	ly 3009120	2.08	7
33	bafetinib	1.95	6
34	Axitinib	0.69	1
35	Dasatinib	0.69	1
36	Sorafenib	0.69	1

About CSK as a Drug Target

CSK (C-terminal Src kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 36 compounds with documented CSK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CSK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.