What compounds target CYP19A1?

BiohacksAI has identified 102 compounds that interact with CYP19A1 (cytochrome P450 family 19 subfamily A member 1). Top compounds include: Letrozole, Fadrozole, Anastrozole, Kaempferols, chrysin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CYP19A1 (cytochrome P450 family)?

CYP19A1 is cytochrome P450 family 19 subfamily A member 1. It is a molecular target for 102 compounds documented in PubMed bioassay data. UniProt ID: P11511. NCBI Gene ID: 1588.

CYP19A1

MOLECULAR TARGET

cytochrome P450 family 19 subfamily A member 1

UniProt: P11511 NCBI Gene: 1588102 compounds

CYP19A1 (cytochrome P450 family 19 subfamily A member 1) is targeted by 102 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CYP19A1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Letrozole	3.99	53
2	Fadrozole	3.74	41
3	Anastrozole	3.00	19
4	Kaempferols	2.30	9
5	chrysin	2.20	8
6	Androstenedione	2.20	8
7	Apigenin 5,7,4'-trihydroxy-flavone,	1.79	5
8	Clotrimazole	1.79	5
9	Methylene Blue	1.61	4
10	Testosterone	1.61	4
11	Bortezomib	1.61	4
12	cycloheximide	1.61	4
13	Ethidium	1.61	4
14	Fulvestrant	1.61	4
15	Lovastatin	1.61	4
16	Miconazole	1.61	4
17	Reserpine	1.61	4
18	Spironolactone	1.61	4
19	Vitamin	1.39	3
20	Dactinomycin	1.39	3
21	Dihydrotestosterone	1.39	3
22	Disulfiram	1.39	3
23	Hexachlorophene	1.39	3
24	mg624	1.39	3
25	Ouabain	1.39	3
26	Rotenone	1.39	3
27	stx64	1.39	3
28	Acetaldehyde	1.10	2
29	Amoxapine	1.10	2
30	Astemizole Antihistamine drug now withdrawn from	1.10	2
31	Azacitidine	1.10	2
32	Azacitidine	1.10	2
33	Celecoxib	1.10	2
34	Cetylpyridinium Cationic bactericidal surfactant used as	1.10	2
35	Chlorhexidine	1.10	2
36	Daunorubicin	1.10	2
37	Digoxin	1.10	2
38	Dinitrochlorobenzene	1.10	2
39	Emetine	1.10	2
40	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	1.10	2
41	Flutamide	1.10	2
42	Nisoldipine	1.10	2
43	Nitrofurantoin	1.10	2
44	ns398	1.10	2
45	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	1.10	2
46	Toxaphene	1.10	2
47	Trabectedin	1.10	2
48	Troglitazone	1.10	2
49	Atorvastatin	0.69	1
50	Kaempferols	0.69	1

Showing top 50 of 102 compounds. Use the BiohacksAI search to explore all CYP19A1 modulators.

About CYP19A1 as a Drug Target

CYP19A1 (cytochrome P450 family 19 subfamily A member 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 102 compounds with documented CYP19A1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CYP19A1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.