What compounds target CYP2C19?

BiohacksAI has identified 334 compounds that interact with CYP2C19 (cytochrome P450 family 2 subfamily C member 19). Top compounds include: Disulfiram, Clotrimazole, Isoniazid Antibacterial agent used primarily as, Levonorgestrel, Norgestrel. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CYP2C19 (cytochrome P450 family)?

CYP2C19 is cytochrome P450 family 2 subfamily C member 19. It is a molecular target for 334 compounds documented in PubMed bioassay data. UniProt ID: P33261. NCBI Gene ID: 1557.

CYP2C19

MOLECULAR TARGET

cytochrome P450 family 2 subfamily C member 19

UniProt: P33261 NCBI Gene: 1557334 compounds

CYP2C19 (cytochrome P450 family 2 subfamily C member 19) is targeted by 334 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CYP2C19

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Disulfiram	2.48	11
2	Clotrimazole	2.20	8
3	Isoniazid Antibacterial agent used primarily as	2.20	8
4	Levonorgestrel	2.20	8
5	Norgestrel	2.20	8
6	Apigenin 5,7,4'-trihydroxy-flavone,	2.08	7
7	Quercetin	2.08	7
8	Ethinyl Estradiol	2.08	7
9	Finasteride	2.08	7
10	Flutamide	2.08	7
11	Methoxsalen	2.08	7
12	Rotenone	2.08	7
13	Androstenedione	1.95	6
14	Carbaryl	1.95	6
15	Chlorhexidine	1.95	6
16	Cimetidine	1.95	6
17	Corticosterone	1.95	6
18	Ethoxyquin Antioxidant; also	1.95	6
19	Fulvestrant	1.95	6
20	Loratadine	1.95	6
21	Vitamin K 3	1.95	6
22	Piribedil	1.95	6
23	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	1.95	6
24	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	1.95	6
25	Tolazamide	1.95	6
26	Genistein	1.79	5
27	Progesterone	1.79	5
28	Colchicine	1.79	5
29	Fenofibrate	1.79	5
30	Lovastatin	1.79	5
31	Mestranol	1.79	5
32	Nisoldipine	1.79	5
33	Phenylbutazone	1.79	5
34	Phenytoin	1.79	5
35	Sulindac	1.79	5
36	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.79	5
37	chrysin	1.61	4
38	Pueraria	1.61	4
39	Dehydroepiandrosterone	1.61	4
40	Fluoxetine	1.61	4
41	Kaempferols	1.61	4
42	Melatonin	1.61	4
43	Methylene Blue	1.61	4
44	propyl gallate	1.61	4
45	Vitamin	1.61	4
46	17-alpha-Hydroxyprogesterone	1.61	4
47	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.61	4
48	Anabasine	1.61	4
49	Anastrozole	1.61	4
50	Carboxin	1.61	4

Showing top 50 of 334 compounds. Use the BiohacksAI search to explore all CYP2C19 modulators.

About CYP2C19 as a Drug Target

CYP2C19 (cytochrome P450 family 2 subfamily C member 19) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 334 compounds with documented CYP2C19 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CYP2C19 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.