What compounds target CYP3A4?

BiohacksAI has identified 224 compounds that interact with CYP3A4 (cytochrome P450 family 3 subfamily A member 4). Top compounds include: Ritonavir, Clotrimazole, Disulfiram, Methoxsalen, Miconazole. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CYP3A4 (cytochrome P450 family)?

CYP3A4 is cytochrome P450 family 3 subfamily A member 4. It is a molecular target for 224 compounds documented in PubMed bioassay data. UniProt ID: P08684. NCBI Gene ID: 1576.

CYP3A4

MOLECULAR TARGET

cytochrome P450 family 3 subfamily A member 4

UniProt: P08684 NCBI Gene: 1576224 compounds

CYP3A4 (cytochrome P450 family 3 subfamily A member 4) is targeted by 224 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CYP3A4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Ritonavir	3.47	31
2	Clotrimazole	2.64	13
3	Disulfiram	2.48	11
4	Methoxsalen	2.48	11
5	Miconazole	2.48	11
6	Apigenin 5,7,4'-trihydroxy-flavone,	2.40	10
7	Glyburide	2.30	9
8	Lovastatin	2.20	8
9	Maprotiline	2.20	8
10	Piribedil	2.20	8
11	Quercetin	2.08	7
12	Ethinyl Estradiol	2.08	7
13	Isoniazid Antibacterial agent used primarily as	2.08	7
14	Leflunomide	2.08	7
15	Piperonyl Butoxide	2.08	7
16	Rotenone	2.08	7
17	Fluoxetine	1.95	6
18	Genistein	1.95	6
19	Aprepitant	1.95	6
20	Celecoxib	1.95	6
21	Dequalinium	1.95	6
22	dilazep	1.95	6
23	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	1.95	6
24	Fulvestrant	1.95	6
25	Levonorgestrel	1.95	6
26	Norgestrel	1.95	6
27	Triamcinolone Acetonide	1.95	6
28	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.95	6
29	Budesonide	1.79	5
30	Testosterone	1.79	5
31	Ethidium	1.79	5
32	Ethoxyquin Antioxidant; also	1.79	5
33	Melphalan	1.79	5
34	Niclosamide	1.79	5
35	Nisoldipine	1.79	5
36	Phenelzine	1.79	5
37	Podophyllotoxin	1.79	5
38	Propanil	1.79	5
39	Sulfaphenazole	1.79	5
40	Vincamine	1.79	5
41	chrysin	1.61	4
42	Pueraria	1.61	4
43	egcg	1.61	4
44	Methylene Blue	1.61	4
45	Simvastatin	1.61	4
46	Vitamin	1.61	4
47	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.61	4
48	Amoxapine	1.61	4
49	Anastrozole	1.61	4
50	Cilostazol	1.61	4

Showing top 50 of 224 compounds. Use the BiohacksAI search to explore all CYP3A4 modulators.

About CYP3A4 as a Drug Target

CYP3A4 (cytochrome P450 family 3 subfamily A member 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 224 compounds with documented CYP3A4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CYP3A4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.