DHFR
MOLECULAR TARGETdihydrofolate reductase
DHFR (dihydrofolate reductase) is targeted by 17 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting DHFR
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | gentamicin | 6.30 | 541 |
| 2 | methotrexate | 6.00 | 404 |
| 3 | trimethoprim | 5.65 | 283 |
| 4 | pyrimethamine | 5.36 | 211 |
| 5 | Methotrexate | 5.02 | 150 |
| 6 | diflunisal | 4.17 | 64 |
| 7 | mefenamic acid | 3.93 | 50 |
| 8 | raltitrexed | 3.58 | 35 |
| 9 | teriflunomide | 3.56 | 34 |
| 10 | brequinar | 3.37 | 28 |
| 11 | Pemetrexed | 3.14 | 22 |
| 12 | dideazafolate | 2.40 | 10 |
| 13 | pralatrexate | 2.08 | 7 |
| 14 | egcg | 0.69 | 1 |
| 15 | Folic Acid | 0.69 | 1 |
| 16 | Leucovorin | 0.69 | 1 |
| 17 | Sulfadiazine | 0.69 | 1 |
About DHFR as a Drug Target
DHFR (dihydrofolate reductase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 17 compounds with documented DHFR interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
DHFR inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.