What compounds target DRD2?

BiohacksAI has identified 114 compounds that interact with DRD2 (dopamine receptor D2). Top compounds include: Raclopride, Buspirone, Domperidone, Metoclopramide, Pergolide. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is DRD2 (dopamine receptor D2)?

DRD2 is dopamine receptor D2. It is a molecular target for 114 compounds documented in PubMed bioassay data. UniProt ID: P14416. NCBI Gene ID: 1813.

DRD2

MOLECULAR TARGET

dopamine receptor D2

UniProt: P14416 NCBI Gene: 1813114 compounds

DRD2 (dopamine receptor D2) is targeted by 114 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting DRD2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Raclopride	3.40	29
2	Buspirone	3.26	25
3	Domperidone	2.94	18
4	Metoclopramide	2.89	17
5	Pergolide	2.83	16
6	Pramipexole	2.83	16
7	Aripiprazole	2.77	15
8	Sulpiride	2.71	14
9	Bromocriptine	2.48	11
10	Butaclamol	2.48	11
11	Amoxapine	2.40	10
12	Amisulpride	2.30	9
13	Levalbuterol	2.20	8
14	Levalbuterol	2.20	8
15	Phenoxybenzamine	2.20	8
16	Yohimbine	2.20	8
17	Cyproheptadine	2.08	7
18	Perphenazine	2.08	7
19	Flunarizine Flunarizine is	1.95	6
20	Fluspirilene	1.95	6
21	Loxapine	1.95	6
22	oxatomide [Supplementary Concept] structure;	1.95	6
23	Mianserin	1.79	5
24	Quetiapine Fumarate	1.79	5
25	Dihydroergotamine	1.79	5
26	Lisuride	1.79	5
27	Metergoline	1.79	5
28	pirenperone	1.79	5
29	Thioridazine	1.79	5
30	Tiapride Hydrochloride	1.79	5
31	triflupromazine hydrochloride	1.79	5
32	Adenosine Monophosphate Adenine nucleotide containing	1.61	4
33	Clenbuterol	1.61	4
34	Cyclic AMP	1.61	4
35	Cyclic AMP	1.61	4
36	Deferasirox	1.61	4
37	Dinoprostone	1.61	4
38	Epinephrine	1.61	4
39	Etodolac	1.61	4
40	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	1.61	4
41	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	1.61	4
42	Loxapine	1.61	4
43	Nicergoline	1.61	4
44	Norepinephrine Precursor of epinephrine that is secreted by	1.61	4
45	Nylidrin	1.61	4
46	Piribedil	1.61	4
47	Promazine	1.61	4
48	propionylpromazine hydrochloride	1.61	4
49	Ranitidine	1.61	4
50	Salmeterol Xinafoate	1.61	4

Showing top 50 of 114 compounds. Use the BiohacksAI search to explore all DRD2 modulators.

About DRD2 as a Drug Target

DRD2 (dopamine receptor D2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 114 compounds with documented DRD2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

DRD2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.