What compounds target DRD3?

BiohacksAI has identified 126 compounds that interact with DRD3 (dopamine receptor D3). Top compounds include: Pramipexole, Aripiprazole, Sulpiride, Pergolide, Butaclamol. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is DRD3 (dopamine receptor D3)?

DRD3 is dopamine receptor D3. It is a molecular target for 126 compounds documented in PubMed bioassay data. UniProt ID: P35462. NCBI Gene ID: 1814.

DRD3

MOLECULAR TARGET

dopamine receptor D3

UniProt: P35462 NCBI Gene: 1814126 compounds

DRD3 (dopamine receptor D3) is targeted by 126 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting DRD3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Pramipexole	3.71	40
2	Aripiprazole	3.50	32
3	Sulpiride	2.71	14
4	Pergolide	2.56	12
5	Butaclamol	2.48	11
6	Bromocriptine	2.40	10
7	Domperidone	2.40	10
8	Raclopride	2.40	10
9	Quetiapine Fumarate	2.20	8
10	Mianserin	1.95	6
11	Cabergoline	1.95	6
12	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.79	5
13	Lisuride	1.61	4
14	Loxapine	1.61	4
15	Metoclopramide	1.61	4
16	Piribedil	1.61	4
17	Yohimbine	1.61	4
18	Amisulpride	1.39	3
19	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.39	3
20	Buspirone	1.39	3
21	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	1.39	3
22	Maprotiline	1.39	3
23	Metergoline	1.39	3
24	Methylergonovine	1.39	3
25	nafadotride	1.39	3
26	Amlodipine	1.10	2
27	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.10	2
28	Minocycline	1.10	2
29	1-Butanol	1.10	2
30	Amoxapine	1.10	2
31	Astemizole Antihistamine drug now withdrawn from	1.10	2
32	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	1.10	2
33	Bisphenol A-Glycidyl Methacrylate	1.10	2
34	butanols	1.10	2
35	Ciclopirox	1.10	2
36	Cinnarizine	1.10	2
37	Cyproheptadine	1.10	2
38	Dihydroergotamine	1.10	2
39	dofetilide	1.10	2
40	Ergonovine	1.10	2
41	Fluspirilene	1.10	2
42	Secologanin Tryptamine Alkaloids Compounds formed by condensation of secologanin with tryptamine resulting in	1.10	2
43	lidoflazine	1.10	2
44	Loratadine	1.10	2
45	Vitamin K 3	1.10	2
46	Mestranol	1.10	2
47	Miconazole	1.10	2
48	3',4'-didemethylnobiletin [Supplementary Concept]	1.10	2
49	oxatomide [Supplementary Concept] structure;	1.10	2
50	Pentostatin	1.10	2

Showing top 50 of 126 compounds. Use the BiohacksAI search to explore all DRD3 modulators.

About DRD3 as a Drug Target

DRD3 (dopamine receptor D3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 126 compounds with documented DRD3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

DRD3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.