What compounds target EPHA5?

BiohacksAI has identified 31 compounds that interact with EPHA5 (EPH receptor A5). Top compounds include: gefitinib, erlotinib, alvocidib, foretinib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHA5 (EPH receptor A5)?

EPHA5 is EPH receptor A5. It is a molecular target for 31 compounds documented in PubMed bioassay data. UniProt ID: P54756. NCBI Gene ID: 2044.

EPHA5

MOLECULAR TARGET

EPH receptor A5

UniProt: P54756 NCBI Gene: 204431 compounds

EPHA5 (EPH receptor A5) is targeted by 31 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHA5

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	alvocidib	4.52	91
4	foretinib	4.34	76
5	vandetanib	4.30	73
6	ponatinib	4.26	70
7	nilotinib	4.17	64
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	regorafenib	3.56	34
11	canertinib	3.53	33
12	pelitinib	3.50	32
13	tae 684	3.43	30
14	linifanib	3.33	27
15	mln 8054	3.33	27
16	saracatinib	3.33	27
17	neflamapimod	3.30	26
18	dasatinib anhydrous	3.09	21
19	lestaurtinib	3.04	20
20	danusertib	2.94	18
21	r 406	2.83	16
22	milciclib	2.77	15
23	gsk 690693	2.64	13
24	tivozanib	2.64	13
25	ast 487	2.56	12
26	golvatinib	2.20	8
27	cep 32496	1.95	6
28	bafetinib	1.95	6
29	sapitinib	1.95	6
30	Sorafenib	1.39	3
31	Crizotinib	0.69	1

About EPHA5 as a Drug Target

EPHA5 (EPH receptor A5) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 31 compounds with documented EPHA5 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHA5 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.