What compounds target EPHB2?

BiohacksAI has identified 28 compounds that interact with EPHB2 (EPH receptor B2). Top compounds include: sb 203580, foretinib, tozasertib, vandetanib, ponatinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHB2 (EPH receptor B2)?

EPHB2 is EPH receptor B2. It is a molecular target for 28 compounds documented in PubMed bioassay data. UniProt ID: P29323. NCBI Gene ID: 2048.

EPHB2

MOLECULAR TARGET

EPH receptor B2

UniProt: P29323 NCBI Gene: 204828 compounds

EPHB2 (EPH receptor B2) is targeted by 28 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHB2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	sb 203580	4.92	136
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	vandetanib	4.30	73
5	ponatinib	4.26	70
6	nilotinib	4.17	64
7	bosutinib	4.08	58
8	doramapimod	4.06	57
9	canertinib	3.53	33
10	tae 684	3.43	30
11	fedratinib	3.40	29
12	linifanib	3.33	27
13	saracatinib	3.33	27
14	dasatinib anhydrous	3.09	21
15	lestaurtinib	3.04	20
16	danusertib	2.94	18
17	r 406	2.83	16
18	milciclib	2.77	15
19	tivozanib	2.64	13
20	ast 487	2.56	12
21	poziotinib	2.48	11
22	rebastinib	2.20	8
23	golvatinib	2.20	8
24	cyc 116	2.08	7
25	bafetinib	1.95	6
26	sapitinib	1.95	6
27	Sorafenib	1.61	4
28	Dasatinib	0.69	1

About EPHB2 as a Drug Target

EPHB2 (EPH receptor B2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 28 compounds with documented EPHB2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHB2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.