What compounds target EPHB4?

BiohacksAI has identified 42 compounds that interact with EPHB4 (EPH receptor B4). Top compounds include: gefitinib, erlotinib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHB4 (EPH receptor B4)?

EPHB4 is EPH receptor B4. It is a molecular target for 42 compounds documented in PubMed bioassay data. UniProt ID: P54760. NCBI Gene ID: 2050.

EPHB4

MOLECULAR TARGET

EPH receptor B4

UniProt: P54760 NCBI Gene: 205042 compounds

EPHB4 (EPH receptor B4) is targeted by 42 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHB4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	ponatinib	4.26	70
7	nilotinib	4.17	64
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	nintedanib	3.61	36
11	canertinib	3.53	33
12	pelitinib	3.50	32
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	linifanib	3.33	27
16	mln 8054	3.33	27
17	saracatinib	3.33	27
18	neflamapimod	3.30	26
19	alisertib	3.30	26
20	dasatinib anhydrous	3.09	21
21	lestaurtinib	3.04	20
22	danusertib	2.94	18
23	r 406	2.83	16
24	cediranib	2.83	16
25	milciclib	2.77	15
26	Sorafenib	2.64	13
27	kw 2449	2.64	13
28	tivozanib	2.64	13
29	poziotinib	2.48	11
30	aee 788	2.30	9
31	rebastinib	2.20	8
32	golvatinib	2.20	8
33	cyc 116	2.08	7
34	ly 3009120	2.08	7
35	cep 32496	1.95	6
36	bafetinib	1.95	6
37	maleimide	1.95	6
38	bastadin 7	1.95	6
39	sapitinib	1.95	6
40	Crizotinib	0.69	1
41	Dasatinib	0.69	1
42	tyrphostin ag 1478	0.69	1

About EPHB4 as a Drug Target

EPHB4 (EPH receptor B4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 42 compounds with documented EPHB4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHB4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.