What compounds target EPHB6?

BiohacksAI has identified 48 compounds that interact with EPHB6 (EPH receptor B6). Top compounds include: gefitinib, erlotinib, sb 203580, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHB6 (EPH receptor B6)?

EPHB6 is EPH receptor B6. It is a molecular target for 48 compounds documented in PubMed bioassay data. UniProt ID: O15197. NCBI Gene ID: 2051.

EPHB6

MOLECULAR TARGET

EPH receptor B6

UniProt: O15197 NCBI Gene: 205148 compounds

EPHB6 (EPH receptor B6) is targeted by 48 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHB6

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	sb 203580	4.92	136
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	vandetanib	4.30	73
7	ruxolitinib	4.23	68
8	nilotinib	4.17	64
9	bosutinib	4.08	58
10	quizartinib	3.99	53
11	midostaurin	3.85	46
12	pazopanib	3.69	39
13	neratinib	3.66	38
14	nintedanib	3.61	36
15	canertinib	3.53	33
16	tae 684	3.43	30
17	fedratinib	3.40	29
18	gilteritinib	3.40	29
19	linifanib	3.33	27
20	saracatinib	3.33	27
21	dabrafenib	3.30	26
22	tandutinib	3.22	24
23	dovitinib	3.09	21
24	at 9283	3.09	21
25	dasatinib anhydrous	3.09	21
26	lestaurtinib	3.04	20
27	adavosertib	3.04	20
28	danusertib	2.94	18
29	defosbarasertib	2.89	17
30	r 406	2.83	16
31	cediranib	2.83	16
32	pha 665752	2.71	14
33	plx 4720	2.71	14
34	kw 2449	2.64	13
35	raf 265	2.48	11
36	brivanib	2.48	11
37	tak 285	2.40	10
38	su 014813	2.20	8
39	gsk 1070916	2.20	8
40	golvatinib	2.20	8
41	cyc 116	2.08	7
42	osi 632	1.79	5
43	fgfr inhibitor debio 1347	1.79	5
44	Crizotinib	1.10	2
45	Sorafenib	1.10	2
46	Afatinib	0.69	1
47	Axitinib	0.69	1
48	pictilisib	0.69	1

About EPHB6 as a Drug Target

EPHB6 (EPH receptor B6) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 48 compounds with documented EPHB6 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHB6 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.